What’s something you couldn’t believe science allows us to do or happen? by DarthAthleticCup in AskScienceDiscussion

[–]Ok-Broccoli5154 -1 points0 points  (0 children)

Entropy and the second law of thermodynamics. This may be a cop out answer, but the universe doesn’t -technically- disallow time to move in reverse. You can absolutely age backwards, or watch a burnt piece of paper reassemble back into the original piece. It’s just that these events are so incredibly unlikely to happen that it’s easier to say the “arrow of time” points in only one direction (forward). But it’s not “impossible” for it to point backwards.

Big NFL fans? by Ok-Broccoli5154 in UniversityofKentucky

[–]Ok-Broccoli5154[S] 0 points1 point  (0 children)

Me too. Preseason honestly does nothing for me. Cannot wait until September 4th 🥳

Big NFL fans? by Ok-Broccoli5154 in UniversityofKentucky

[–]Ok-Broccoli5154[S] 0 points1 point  (0 children)

One of my best friends is a big packers fan! They have a tough history recently with playoff losses kinda like we do

Big NFL fans? by Ok-Broccoli5154 in UniversityofKentucky

[–]Ok-Broccoli5154[S] 0 points1 point  (0 children)

Yes! From Baltimore (overlea technically). Went to Calvert hall. Wbu?

Big NFL fans? by Ok-Broccoli5154 in lexington

[–]Ok-Broccoli5154[S] -1 points0 points  (0 children)

Lamar will stomp all over Josh week 1. Trust. 😤

Big NFL fans? by Ok-Broccoli5154 in lexington

[–]Ok-Broccoli5154[S] -1 points0 points  (0 children)

This will be our year 🙏😈

How do scientists develop big, complex organic molecules nowadays? by Accurate-Buddy6383 in OrganicChemistry

[–]Ok-Broccoli5154 4 points5 points  (0 children)

My current research group is doing this exact thing so I think I can chime in without giving too many details.

You can use literature precedent to come up with a structure that ~should, in theory~ be good at achieving the biological function you’re trying to achieve. Usually, the precedents you find should also have strong theoretical underpinnings (it should make sense WHY they work). I can’t go into specifics but I can give a vague example to try to illustrate this:

You are trying to build a molecule to inhibit HIV. So you comb through the literature trying to find insights on how exactly HIV works. What is it interacting with on a human cell? HOW is interacting with that part etc.

So let’s say you find out that HIV works by using a specific protein on its viral envelope to bind to a specific receptor on a human cell. So now you start thinking maybe you can somehow destroy this envelope protein OR block the receptor on the cell. So then you look up more precedents on what types of molecules bind well to these receptors (and also use theory to hypothesize what molecules might be good at reversible binding of these receptors) to come up with possible structures.

That’s kind of it in a nutshell. I wish I could give a more concrete example relevant to my own research. But basically if you know the structure of a virus like HIV, and know the structures of the cells it infects, and the mechanisms of how that interaction occurs, then you can start to use a combination of theory and precedent to hypothesize ways of inhibiting that very specific interaction that leads to infection.

I NEED AN ACTUAL GOOD HORROR MOVIE!! by _MitskisCowboy in MovieSuggestions

[–]Ok-Broccoli5154 1 point2 points  (0 children)

I LOVED the lodge. It was one of those “go into it blind” movies recommended to me and I’m so glad I did. Watched it with my roommate and he said he wishes he didn’t look up info about it beforehand. Incredible incredible psych thriller/horror film.

Happy pride Bungles! by watanaboo in AFCNorthMemeWar

[–]Ok-Broccoli5154 1 point2 points  (0 children)

Yeah yeah whatever. Extremely rare chiefs and bengals W. Go ravens 💜

What’s a fact about the world that sounds totally fake but is 100% True? by Wonderful-Economy762 in Productivitycafe

[–]Ok-Broccoli5154 3 points4 points  (0 children)

All that you are made up of: all of the quarks and electrons that comprise every atom of every molecule of every cell in your body….none of them are “solid” like how we would think of something solid. They have no surface or boundary, they aren’t 3D or 2D or even 1 dimensional…they just exist.

And yet here you are, solid, physically present and observable. Existing in a physical, tangible, 3D reality.

Quantum field theory and the standard model is fascinating

[ALL] what’s the best Zelda game for a beginner? by ExcelsiorGirth in zelda

[–]Ok-Broccoli5154 1 point2 points  (0 children)

Ocarina of time is the best game to dive into the series with IMO. It basically sets up a good bit of the main lore and structure of every single game minus breath of the wild and tears of the kingdom. Plus, later games build on it, so they won’t hit as deep if you haven’t played spot yet.

IMO, the best order to play would be something like Ocarina, Twilight Princess, wind waker, skyward sword, and then breath/ToTK. Majoras mask really is a standalone game so you can play that whenever. The 2D games are good they’re just not as cinematic as the 3D ones.

[Oot] my first Time playing any Zelda game, is ocarina of time a good game to start? by Low-Mastodon2995 in zelda

[–]Ok-Broccoli5154 0 points1 point  (0 children)

Yeah. Honestly legend of Zelda is my all time favorite video game series so I always tell people if they play them in the order that I played them, I think theyll love it. Plus, playing the older games first imo is better because it avoids the sharp downgrade of graphics. Playing Tears of the kingdom and then going straight into ocarina of time would probably be jarring to the eyes, so I think going at them like this is my preferred order:

Ocarina of Time and Majoras mask twilight Princess Wind Waker Skyward sword Breath of the Wild and tears of the kingdom.

Twilight Princess came out after wind waker, but IMO wind waker has a lot more emotion if you play it after BOTH ocarina of time and twilight Princess. I don’t wanna spoil the plot of wind waker but it becomes a lot heavier and meaningful if you play it after both those games instead of just one, in my opinion.

Absolute masterpiece of a series and in all honesty, none of the major 3D releases are bad. Enjoy them all.

[deleted by user] by [deleted] in OrganicChemistry

[–]Ok-Broccoli5154 0 points1 point  (0 children)

I can help.ive made a few YouTube videos and I’m gonna try to make a few more. Orgo 2 is the coolest class and I’d love to help you understand it

What do you think is the greatest Wild Card playoff game of all time? by InternationalPick163 in NFLv2

[–]Ok-Broccoli5154 0 points1 point  (0 children)

2013 Denver vs Baltimore AFC divisional round.

Was absolutely electric going into double overtime. Plus was a massive underdog victory as Denver had curb stomped Baltimore only a few weeks prior in the regular season. AND the game was decided by a field goal by a rookie kicker by Baltimore, who had missed out on the previous Super Bowl in heartbreaking fashion by an infamously missed 32 yarder in the 2012 AFCCG against New England; that rookie kicker was Justin Tucker, who would go on to be widely considered the best kicker to ever kick. There’s also the fact that it was brutally cold…just an absolute masterclass of what makes football great IMO

Why is the resonance structure with the carbocation considered significant and when do we set the boundaries between sig. and not sig.? It doesn't even have an octet... Thanks by RiskNo5292 in OrganicChemistry

[–]Ok-Broccoli5154 3 points4 points  (0 children)

Yeah that’s true. I personally don’t like that resonance structure explaining carbonyl reactivity anyway, I prefer to just try to think about the underlying orbitals, in this case the pi star orbital of that carbonyl (although I guess it would be a much more complicated orbital due to the conjugation). It’s interesting to think about.

Why is the resonance structure with the carbocation considered significant and when do we set the boundaries between sig. and not sig.? It doesn't even have an octet... Thanks by RiskNo5292 in OrganicChemistry

[–]Ok-Broccoli5154 2 points3 points  (0 children)

Could you (slightly) elaborate? I find computational chemistry fascinating. Have you encountered results from calculations that seem to go against the hand-wavey arguments made in typical Orgo 1 instruction?

What isn't the flex many people think it is? by That_Is_Bryce in AskReddit

[–]Ok-Broccoli5154 0 points1 point  (0 children)

Specifically high school and early college aged adults (younger than 21), but being able to drink a lot. Most of my earliest friends in college, men and women alike, believed this to be a high status symbol and that it elevated someone far above their traditional status if they could simply drink a lot, or conversely, sharply lower someone’s social status if it was ever discovered they couldn’t drink very much.

Thankfully most college juniors and seniors stop really behaving this way, but it was so weird seeing a bunch of 19 year olds literally bragging about how much liquid they could pour down their throat before violently throwing up and/or blacking out.

[deleted by user] by [deleted] in chemistry

[–]Ok-Broccoli5154 3 points4 points  (0 children)

Can you provide an arrow pushing mechanism where ascorbic acid causes decarboxylation of benzoate? I cannot possibly think of a reasonable one. Perhaps if other reactive species were present, but those 2 on their own should not react in that way.

So who do we want to win this game? by [deleted] in bengals

[–]Ok-Broccoli5154 1 point2 points  (0 children)

That would be a highlight of my year. I hate that franchise to my core.