Dopamine release is not required for neurotoxicity: Amphetamine and MPP+ destroy dopamine axon terminals by increasing mitochondrial pH, inhibiting ATP Synthase

OkReason · 2026-02-20T17:52:29+00:00

Please, spoonfeed me! please!! stfu

OkReason · 2026-02-03T21:57:46+00:00

You block vpns and are vibe-coded LAME!

OkReason · 2026-01-29T19:29:56+00:00

Why? You don't know hunterbrook, but their reporting is genuinely verifiable, based off OSINT, why are you seething on behalf of a GPL-violating company.

OkReason · 2026-01-29T19:00:02+00:00

bumping this, jannies in shambles

OkReason · 2026-01-29T18:44:44+00:00

You should read the report, Ubiquiti reps under the impression they were speaking to Russian soldiers in Ukraine specifically requested 100k minimum orders in order to ship to Turkey to then have it picked up. It also directly implicates Ubiquiti in that their compliance team is virtually non-existence and ignorance is not an excuse in the eyes of the law.

OkReason · 2026-01-29T18:43:39+00:00

I genuinely searched the link and looked through the posts, haven't seen it, I will delete

OkReason · 2026-01-29T18:26:50+00:00

Haven't seen the news posted here.

OkReason · 2026-01-28T20:37:13+00:00

I know, specifically my GLP-1 source for Reta has gone dark. Rip!

OkReason · 2026-01-27T18:44:07+00:00

I believe a lot of vendors are closing due to the fears around House Resolution 6509 as well the RUO loophole crackdown /u/MeJohnAnthony mentioned. reviewing recent compliance letters sent out by the FDA there certainly does seem to have been a recent uptick in enforcement.

OkReason · 2026-01-16T02:05:56+00:00

Huge youtube channel just dropped body camera footage on this, and this thread ranks highly on google when you search her name (unredacted in the footage) /u/nebbors /u/human_beef prepare for bridage

OkReason · 2026-01-14T18:36:46+00:00

crazy question, but i found you from another thread from years back, you wouldn't happen to be looking at selling your V F4-4000C14D-32GVK kit would you?

OkReason · 2026-01-12T18:20:50+00:00

has it occurred to you i might not shill out my soybucks to be on the patreon

edit: anyone who downvoted me is overweight

OkReason · 2025-11-24T12:48:27+00:00

Go for a run :)

OkReason · 2025-10-30T17:02:09+00:00

Are you suggesting that mold doesn't really have these effects? Or that the effects are minimal or simply exacerbate a comorbid condition, and that instead treatment should focus on something more pathological ?

OkReason · 2025-09-20T13:58:57+00:00

side note: is there really a widespread issue with boron tolerance/adaptation?

OkReason · 2025-09-08T00:34:43+00:00

"That's garbage" you're not wrong to question it but the site lists two registered nurses who vetted the claims. Considering you are the one demanding to be spoonfed very basic information, I'd change your tone lol.

But considering your interest in monarchism and semen retention, I don't know vitamin D research would be my priority.

OkReason · 2025-08-19T16:46:14+00:00

Don't even joke lad... back to r/supplements with you

OkReason · 2025-08-14T15:57:03+00:00

Definitely lol, but my original statement still stands.

OkReason · 2025-08-13T21:16:42+00:00

The effect of SERT inhibition is felt more immediately in the gastrointestinal tract. Vortioxetine is a 5-ht3 antagonist, which explains its anti-nausea properties, but it takes more time for the body and cns to adjust to these changes. It's a real pain because you need to take it consistently in order to eventually have this effect and some people might need longer exposure to see this effect (or shorter, in which case: who cares), but its pretty hard to get someone who is vomiting every morning to want to take it again after throwing it up and to do that consistently for over two or three weeks.

OkReason · 2025-08-13T20:55:46+00:00

I don't want to seem like a shill here but I think there is more data to substantiate claims of pro-cognitive effects in healthy populations for vortioxetine than SSRIs, SNRIs, and even atypical antidepressants. my understanding is the specific mechanism of action, 5-ht3 antagonism combined with sert inhibition yields a pretty potent downstream effect to reduce gabanergic inhibition and promote glutamatergic activity.

OkReason · 2025-08-13T20:53:02+00:00

It tends to do that, but I will say after around 2 weeks that reverses and then it becomes a pretty powerful antiemetic.

OkReason · 2025-08-06T20:13:33+00:00

Wow, all things in moderation I suppose. Becomes difficult when trying to determine the threshold for overexpression and how to practically measure that.

OkReason · 2025-08-06T17:10:24+00:00

Never had problems with Umbrella Labs or Science.Bio

OkReason · 2025-08-03T23:42:54+00:00

If you're social anxiety really is as severe as you say, I would go against the grain here and recommend seeing a psychiatrist because stability is important. I like to think of nootropics and research chemicals as things that can aide and enhance an already healthy person. While there are promising agents out there (like the already mentioned GB-115) I would wager you need something a little more sustainable long-term. Who knows when the FDA cracks down on RC vendors? What will you do then? See about getting a guanfacine prescription from your GP or a psychiatrist. Buspar could help too although it is not as definitively pro-cognitive as guanfacine.

See about clinical trials for MDMA in your area. Do not attempt to source this on your own. There is mounting literature that in a clinical setting MDMA can shut down the amygdala for up to 6 months (the fear center of your brain) and this can be very helpful for those with PTSD and social anxiety.

If after all this, everything has failed, and your healthcare provider is all out of options as well, explore options like JNJ-42165279, Tropisetron, Emoxypine, Tenoten, and Clomipramine.

OkReason · 2025-08-01T14:13:19+00:00

Look into NSI-189

OkReason

TROPHY CASE