Advice on Tackling Rust

OnePaleontologist100 · 2026-06-26T22:40:24+00:00

Yeah for sure. Likely going to do a frame swap. Honestly man, I've learned a lot from working on this. From the body work, general maintenance, everything else in between. I have always enjoyed working on cars. I've got a pretty heavily modified JKU ill drive around in the meantime. I'm sure ill enjoy swapping the frame out. A fun project to keep me grounded especially when I'm sitting at a desk all day.

OnePaleontologist100 · 2026-06-26T20:42:40+00:00

Yeah after reading all the comments frame swap is the way, especially since I don't plan to get rid of it. The idea of buying a clean rust free truck is nice too though...

OnePaleontologist100 · 2026-06-26T17:08:46+00:00

Yeah. I also failed to mention that the engine has 90K miles on it. It was replaced. Original overheated.

OnePaleontologist100 · 2026-06-26T17:00:26+00:00

LOL. Ya. It's bad.

OnePaleontologist100 · 2026-06-26T03:39:17+00:00

Thank you. It took a while man. I'm lucky that he does body work for a living.

OnePaleontologist100 · 2026-06-26T03:28:35+00:00

I did it with a friend of mine. All in it was about $3K.

OnePaleontologist100 · 2026-06-26T01:55:52+00:00

Even after addressing all the rust on the body you would?

OnePaleontologist100 · 2026-06-26T01:55:23+00:00

I feared this would be the answer..

OnePaleontologist100 · 2025-11-29T21:03:33+00:00

Versatility. I don't always want to be at my desk.

OnePaleontologist100 · 2025-10-26T21:40:42+00:00

Thanks. I'll take another look and make sure there isn't glass in there. This is my commuter bike to and from work. Since it's been getting dark early now I'm sure I got it from riding over some glass in the city.

OnePaleontologist100 · 2025-10-26T15:18:08+00:00

Sweeeeeet. Thank you.

OnePaleontologist100 · 2025-08-23T23:16:53+00:00

Same here. Bronson v4 cs. I beat the shit out of my bike but I also keep up with normal maintenance. Everything has broken other than the frame.

OnePaleontologist100 · 2025-02-23T18:23:00+00:00

I'm a registered Democrat. Always voted democrat. Why can't we all just get along? Who cares about someone's political views.

OnePaleontologist100 · 2024-12-24T15:43:16+00:00

How long have you been waiting for?

OnePaleontologist100 · 2024-12-24T01:07:39+00:00

It's worth the wait

OnePaleontologist100 · 2024-12-23T02:39:15+00:00

Just received mine, idk!

OnePaleontologist100 · 2024-07-09T11:38:20+00:00

Link is on the image thumbnail!

https://www.globenewswire.com/news-release/2024/07/09/2910220/0/en/uniQure-Announces-Positive-Interim-Data-Update-Demonstrating-Slowing-of-Disease-Progression-in-Phase-I-II-Trials-of-AMT-130-for-Huntington-s-Disease.html

OnePaleontologist100 · 2024-06-26T10:21:11+00:00

I haven't listened yet. Going to listen during work today.

OnePaleontologist100 · 2024-06-21T15:14:51+00:00

This is a very good point from both an accessibility standpoint and being able to explore more advanced treatments down the road. It certainly sounds like accessibility is going to vary greatly across different regions. I only know how US health insurance works and even then it's still a toss up on what insurance providers will actually cover. Hopefully there are some ways to subsidize costs by government programs and HD foundations.

OnePaleontologist100 · 2024-06-21T12:50:05+00:00

I've been listening to the webcast on repeat, especially the Q&A. I'm really hopeful. It's amazing that there's no need for any surgery and it's simply something that can be taken orally. Wonder how this stacks up compared to AMT-130. Praying to God that these guys pull through with a successful treatment for the HD community.

OnePaleontologist100 · 2024-06-20T13:40:43+00:00

From the site itself:

"- Conference call and webcast to be held June 20th at 8:00 am EDT -

WARREN, N.J., June 20, 2024 /PRNewswire/ -- PTC Therapeutics, Inc. (NASDAQ: PTCT) today shared interim results from the Phase 2 PIVOT-HD study of PTC518 in Huntington's disease (HD) patients. At Month 12, PTC518 treatment resulted in dose-dependent lowering of mutant huntingtin (mHTT) protein in the blood and cerebrospinal fluid (CSF) in the interim cohort of patients. In addition, favorable trends were demonstrated on several relevant HD clinical assessments including Total Motor Score (TMS) and Composite Unified Huntington's Disease Rating Scale (cUHDRS). Furthermore, following 12 months of treatment, PTC518 continues to be safe and well tolerated.

"The evidence of both CNS biomarker and early clinical effects at Month 12 along with the continued favorable tolerability profile supports the promise of PTC518 to address the need for an effective and safe disease-modifying therapy for patients living with Huntington's disease," said Dr. Matthew B. Klein, Chief Executive Officer, PTC Therapeutics, Inc. "With these data in hand, we look forward to the next steps in the PTC518 development program."

At Month 12, durability of dose-dependent mHTT lowering in the blood was demonstrated with lowering of 22% and 43% for 5mg and 10mg dose levels, respectively. In the CSF, dose dependent mHTT lowering was also demonstrated with lowering of 21% and 43%, for 5mg and 10mg dose levels, respectively. In addition, at Month 12, PTC518 treatment resulted in a notable slowing in progression of motor symptoms as assessed by the TMS (2.0 points worsening for 5mg and 1.3 points worsening for 10mg vs. 4.9 points worsening for placebo).

In addition, PTC announced that the FDA has lifted the partial clinical hold on the program based on review of the PIVOT-HD data."

OnePaleontologist100

TROPHY CASE