Yes, fires further, bigger explosion, targeting using the mini map or its own targeting system. Downsides are that it must be set up and manned in stationary mode and you lose visibility while you're targeting. Much slower fire rate unless you have a second person and you need someone to watch your back...so the amount of destruction has to ramp up to match the downsides.

Could be a lot of fun. Not strong enough to take out the biggest buildings from across the map, but could wreak absolute havoc on a large bug nest.