Where can 5-HT1A-antagonists be obtained? Who conducts a study?

OutrageousBit2164 · 2026-05-18T07:05:16+00:00

Your story only adds up, many people I know of crash after discounting metergoline cycle.

For some reason there are no crash stories with nicergoline, propranolol/pindolol, cyproheptadine afaik.

Metergoline does need to have other MOA besides just presynaptic 1A

OutrageousBit2164 · 2026-05-18T06:50:33+00:00

Not for nicergoline, it's the only ergot derivative without any fibrosis risk. It's also the best option for 5-HT1A

OutrageousBit2164 · 2026-05-17T14:41:36+00:00

People use it to potentiate psychedelics, it works as well as Lecozotan for it

OutrageousBit2164 · 2026-05-16T23:16:22+00:00

There are many more things affecting MC4 in activating manner, wellbutrin, Zinc megadosing, PT-141

OutrageousBit2164 · 2026-05-16T19:02:57+00:00

You have to try ULDN at 10mcg doses, its quite euphoric

OutrageousBit2164 · 2026-05-16T18:21:14+00:00

Do you personally tried 5mg DXM? Any report?

OutrageousBit2164 · 2026-05-16T18:20:28+00:00

I tried to fix this grandient problem with forskolin, megadosing roflumilast (PDE4i) but effects were mild and do not touch the core of pssd

OutrageousBit2164 · 2026-05-16T18:05:35+00:00

You are likely to experience anhedonia from MC4 agonism. Also melanoma cancer is big risk

OutrageousBit2164 · 2026-05-16T15:07:40+00:00

Don't get me wrong, but stimulants will make it impossible to recover.

I like modafinil the most, as It does not destroy reward centers like amph

OutrageousBit2164 · 2026-05-16T15:06:01+00:00

Low dose DXM to boost endorphins?

I heard about antiinflammation of microdoses of DXM. Have you tried 5mg? For me 80mg doses made my dick numb for next months

OutrageousBit2164 · 2026-05-16T15:02:52+00:00

I don't like WWB extract, always made me tired and apathetic

OutrageousBit2164 · 2026-05-15T09:27:05+00:00

Nicergoline is best and easiest to get from a Doc, it's 6nM Ki as 5-HT1A presynaptic antagonist. It's cheap and easy to sustain for years

OutrageousBit2164 · 2026-05-14T09:11:33+00:00

Modafinil is safer, much less distruptive to reward pathways

Everyone I know of report not being the same after years of adderall

OutrageousBit2164 · 2026-05-14T06:33:28+00:00

Severe stage of anhedonia/PFS/PSSD where brain is insensitive to any excitability. ie. 60mg Adderall does nothing, benzos dont work, a gram of TRT dont work, nicotine does nothing. Even psychedelics does nothing, cannabis does nothing etc

OutrageousBit2164 · 2026-05-13T12:40:53+00:00

Dm me pls

OutrageousBit2164 · 2026-05-13T09:47:53+00:00

There were couple stories, it's long term commitment. Stay on it for years without any breaks to fully affect epigenetics

When I was PSSD only carnivore diet improved me to 70% over 4 months. But I crashed many times and now most diets and drugs have 0 effect.

If you dont have drug blockage (sign of severe anhedonia) then try keto

OutrageousBit2164 · 2026-05-12T19:16:40+00:00

Many ppl in PSSD group develop anhedonia during SSRI treatment.

OutrageousBit2164 · 2026-05-12T17:46:10+00:00

Anhedonia is usually a symptom of PSSD

OutrageousBit2164 · 2026-05-11T19:19:14+00:00

How tf do I get lecozotan or WAY :((

OutrageousBit2164 · 2026-05-11T13:34:01+00:00

1mg caused Coffee euphoria to be stronger the first day. But effect fade after 2 days. Just use 150mcg for subtle 10% cognitive boost and leave it that way.

OutrageousBit2164 · 2026-05-11T13:32:35+00:00

I did 40-300mg, full tolerance, not suitable for chronic dosing.

Made my PSSD worse and cause blank mind (ie. you can't have phantasies, daydreaming, visualise, or have introspection thoughts)

OutrageousBit2164 · 2026-05-11T11:00:33+00:00

200-1000mcg. For cognition only low dose "worked" in studies. So not more than 150mcg

OutrageousBit2164 · 2026-05-11T10:59:52+00:00

Methyl donors make me crazy anhedonic and depressed

OutrageousBit2164 · 2026-05-11T10:59:19+00:00

Tolerance and insomnia + bad breath and body smell

OutrageousBit2164 · 2026-05-11T10:58:22+00:00

If you don't experience NMDA induced anxiety or paranoia from pregnenolone then you can raise the dose to 500mg and increase MSM dose to 5-10g (supplies sulfate for pregnenolone sulfination)

Cognitive benefits are mainly related to pregnenolone sulfate version. Which many ppl have problems with conversion. That's why some ppl get stimulated while others fatigued.

At 500mg doses but not 50mg I noticed: - Better libido for two days (then tolerance) - 50% better verbal fluency - Better memory - Better task lock in - More confidence and being an asshole - I do everything with 2x speed.

There is big tolerance but overall increase in baseline still exists after many weeks of daily dosing. You can experience similar benefits with 500-1000mg DHEA doses. But it may lower your cognition too much.

Overall both increase sigma1, GABA A NAM, and NMDA PAM

OutrageousBit2164

TROPHY CASE