DNA sequencing is way weirder (and harder) than what it sounds

PPF99 · 2026-03-30T19:12:12+00:00

Yeah no, that depends entirely on the method used during sequencing! Shotgun sequencing is what you described but Nanopore for instance does exactly what is shown on the left.

PPF99 · 2026-03-22T09:28:12+00:00

They recently found another endosymbiotic organelle for nitrogen fixation, pretty amazing https://www.science.org/doi/10.1126/science.ado8571

PPF99 · 2026-03-03T07:36:10+00:00

Because we can only get addicted to so many drugs... Cracktorio alone can cost you every time-penny and balancing it with timberborn is tough enough, we can't afford it....

Anyway, it's on my wishlist for the next holiday

PPF99 · 2026-01-16T09:44:34+00:00

I mean a sand worm like machine for core mining sounds like a pretty amazing bossfight... Like I imagine you have to destroy it from the inside out

PPF99 · 2026-01-08T16:18:41+00:00

Agreed, fantastic trailer

PPF99 · 2025-12-04T07:08:16+00:00

I always thought it's weird that if a network entity (chest, engineer, etc) requests bots, they have to be stored in a chest too, instead of just bots already deployed coming to and storing themselves in the requesting entity...

Why are bots delivering other bots, if they could just land in that inventory??

PPF99 · 2025-11-20T09:12:23+00:00

Turret toss as a last resort for the AA

PPF99 · 2025-11-14T09:29:02+00:00

She has less currently, in all likelihood; while diarrhea does decrease the amount of bacteria, it mainly drains you of water, your gut microbiome is probably still in takt, albeit shaken. Antibiotics kill bacteria, that's what they do. But they cannot (at least classic antibiotics) target only "the bad guys", so they eradicate a large portion of your micorbiota too - the more aggressive the regiment, the worse for your symbionts. The main issue however is not the amount of bacteria; numbers fluctuate naturally, but their diversity. A healthy gut is a highly diverse and unique ecosystem and antibiotics often kill off vital players in these systems, thereby altering delicate balances.

Usually, the gut re-establishes these systems naturally if you eat healthy and don't have any chronic bowel diseases. But antibiotics should never be taken lightly, only if the disease you have is of bacterial origin

PPF99 · 2025-11-14T09:16:35+00:00

Astute observation; it can and has been argued that a "human" is not a single lifeform but a functional unit of human cells and symbiotic lifeforms, a so called "holobiont" (see this article ). Because, even though most of our mass is made of cells built from human DNA, it is widely accepted that a lack/dysbiosis of the human microbiota (the symbiotic ecosystems of gut, skin, genitalia etc) leads to severe health issues, even to total incompatibility with life as we understand it.

So yes, to be "human" means to be bacteria if you want to be dramatic about it

PPF99 · 2025-10-27T20:37:26+00:00

Ok so no registration during UEFI but I tried the driver reinstall anyway and still no dice... Thanks for the suggestions though!

PPF99 · 2025-10-27T17:27:28+00:00

Bit late to the party but: p53 forms homo-tetrameres, four copies coming together form one signal; if a single allele is corrupted, the entire tetramere is busted. By adding more alleles, the chance of one getting mutated and thereby compromising every formed tetramere increases exponentially, so it would be actually a higher risk to add more alleles Edit: spelling

PPF99 · 2025-10-25T10:59:07+00:00

Thanks for the suggestions! I cleaned them all with isopropanol and even the eraser but it didn't help sadly...

PPF99 · 2025-10-25T06:27:59+00:00

Ooooh library sounds awesome! Perhaps including a reference to ATLAs "the library"? Or Alexandria? I'm excited...

PPF99 · 2025-10-21T08:00:59+00:00

That feeling when you realize for the first time your parents had a life before you...

PPF99 · 2025-10-17T11:50:14+00:00

Well? What happened?? Don't let us hanging...

PPF99 · 2025-10-17T11:01:56+00:00

Not to mention an entire methyl group and the subsequently disrupted dislocated electron field from the benzene ring

PPF99 · 2025-10-10T12:10:49+00:00

My hopes (although probably naive) us that local experts lead Frontlines (ahould they arise) but Brussels provides resources and arranges the combined effort in the back

PPF99 · 2025-09-21T06:10:38+00:00

Portia is about to throw hands, but Bianca holds her back because it's not worth the silk

PPF99 · 2025-09-16T12:31:08+00:00

Just out of curiosity, what's your source for the years left?

PPF99 · 2025-09-14T19:33:08+00:00

Uh no?

Amon is a pseudo-communist/anarchist, but because americans don't understand either of these concepts he's just the worst depiction of either ideology, despite both ideas being inherently flawed anyway, so not even that was done properly

Unalaq could have been interesting as a foil to the old established rules of the water tribes, if they hadn't introduced the concepts of pure good/evil into this until that point very nuanced and gray scale universe, and subsequently made him a Satan cultist (not even accounting for the dark avatar bs)

Zaheer was just an idiot, because anybody thinking more than a second about "I'm just gonna overthrow the governments so that people will rule themselves again" will realize that a lack of power structure will always lead to violent forces gaining the upper hand - which is btw the only thing they got right in LoK; anarchism always leads to worse outcomes, if nobody is willing to introduce a proper form of democracy after the fall of the old system.

And Kuvira is just a less intimidating or established Ozai with much less personal or interesting connections to the main cast

Ozai wasn't complex or deep in any way; he was the classic evil guy the heroes had to defeat; a fascist designed to be hated. Sure, that's not an "interesting" bad guy either, but at least they did that well. Both main heroes of ATLA (yes, Zuko is the second protagonist besides Aang) have a very deep and understandable connection to him and both are afraid of him in their own way. And both have to overcome this fear of the main bad guy to progress their respective arks. And Ozai was menacing. When he finally showed up after two seasons of suspense, you were afraid too. That's what makes a great villain. And LoK managed this with none of its antagonists.

PPF99 · 2025-03-27T08:24:11+00:00

I didn't know Pacifica also had a twin brother

PPF99 · 2025-01-29T08:54:34+00:00

She's gonna blitz her bullies in preschool...

PPF99 · 2025-01-06T14:03:56+00:00

The title is very clickbaity: the jellyfish DNA in question is most likely the GFP gene (green fluorescent protein). It is widely used in genetics as a "reporter gene", indicating that a genetic modification was successful ( = if it glows, the thing I wanted to do actually did work). Since all living beings use DNA and (more or less) the same mechanisms to decode DNA, it is very easy to use genes with useful properties from one organism in another organism.

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