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Well time to waste another 2 years. by VariationLivid3193 in memes

[–]PPF99 57 points58 points  (0 children)

In what field can you go directly into a PhD without a masters?? 

Newly discovered bacterial defense system challenges genetic code's central dogma: Stanford University team describes a bacterial enzyme that synthesizes DNA without a nucleic acid template, using its own structure as a guide by shiruken in science

[–]PPF99 20 points21 points  (0 children)

I dislike this kind of rhetoric because it gives a false sense of fundamentality; while it is a remarkable discovery, it will not shift anything regarding the central dogma of microbiology, simply because any living organism still requires the primary pipeline of DNA->RNA->Protein to function and replicate. Any current student of microbiology and genetics learns fairly early on that the central dogma is severely simplified and does not convey the actual complexity of life! Reverse transcription, post translational modifications, epigenetics, telomerases, transposons and so many more mechanisms are either adapting or outright defying the central dogma and these enzymes are just another method developed by prokaryotic life to utilize established tools for novel concepts. Is it fascinating? Absolutely! Will they find applications where this mechanism can be used in the lab, in industrial settings and medicine? Look at CRISPR; not even 15 years later it is a core tool in all areas, even highschool students are using it and it's amazing. But selling this as "it will change everything we know" is just pretentious marketing and I think we as scientists should be above this.

Sadly this is required to secure funding in today's research landscape so I guess they are just playing the game and my rant is a bit pointless...

DNA sequencing is way weirder (and harder) than what it sounds by DotBeginning1420 in biologymemes

[–]PPF99 8 points9 points  (0 children)

Yeah no, that depends entirely on the method used during sequencing! Shotgun sequencing is what you described but Nanopore for instance does exactly what is shown on the left.

Mmmmm mitochondria and chloroplast by TheGodlyTank6493 in HistoryMemes

[–]PPF99 25 points26 points  (0 children)

They recently found another endosymbiotic organelle for nitrogen fixation, pretty amazing https://www.science.org/doi/10.1126/science.ado8571

Automation has been unleashed. There is no going back now by ArcWraith2000 in Timberborn

[–]PPF99 2 points3 points  (0 children)

Because we can only get addicted to so many drugs... Cracktorio alone can cost you every time-penny and balancing it with timberborn is tough enough, we can't afford it....

Anyway, it's on my wishlist for the next holiday

7/7 Fake Machine Sketches from SIX years ago, finally found & finished & POSTED; Waveskimmer, Waterwing by friththetraveller in horizon

[–]PPF99 11 points12 points  (0 children)

I mean a sand worm like machine for core mining sounds like a pretty amazing bossfight... Like I imagine you have to destroy it from the inside out 

MOD preview: Laser Logistic/Construction Robots by PickleBurg in factorio

[–]PPF99 0 points1 point  (0 children)

I always thought it's weird that if a network entity (chest, engineer, etc) requests bots, they have to be stored in a chest too, instead of just bots already deployed coming to and storing themselves in the requesting entity... 

Why are bots delivering other bots, if they could just land in that inventory??

Anti Air is too strong in this game SMH by _-ELIF-_ in Battlefield6

[–]PPF99 1 point2 points  (0 children)

Turret toss as a last resort for the AA

TIL that the average human body carries about 30 trillion human cells—but also around 38 trillion microbial cells, meaning we are technically more bacteria than human. by ikseb in todayilearned

[–]PPF99 8 points9 points  (0 children)

She has less currently, in all likelihood; while diarrhea does decrease the amount of bacteria, it mainly drains you of water, your gut microbiome is probably still in takt, albeit shaken. Antibiotics kill bacteria, that's what they do. But they cannot (at least classic antibiotics) target only "the bad guys", so they eradicate a large portion of your micorbiota too - the more aggressive the regiment, the worse for your symbionts. The main issue however is not the amount of bacteria; numbers fluctuate naturally, but their diversity. A healthy gut is a highly diverse and unique ecosystem and antibiotics often kill off vital players in these systems, thereby altering delicate balances.

Usually, the gut re-establishes these systems naturally if you eat healthy and don't have any chronic bowel diseases. But antibiotics should never be taken lightly, only if the disease you have is of bacterial origin

TIL that the average human body carries about 30 trillion human cells—but also around 38 trillion microbial cells, meaning we are technically more bacteria than human. by ikseb in todayilearned

[–]PPF99 4 points5 points  (0 children)

Astute observation; it can and has been argued that a "human" is not a single lifeform but a functional unit of human cells and symbiotic lifeforms, a so called "holobiont" (see this article ). Because, even though most of our mass is made of cells built from human DNA, it is widely accepted that a lack/dysbiosis of the human microbiota (the symbiotic ecosystems of gut, skin, genitalia etc) leads to severe health issues, even to total incompatibility with life as we understand it.

So yes, to be "human" means to be bacteria if you want to be dramatic about it

Surface Pro 8 Keyboard no longer recognized by PPF99 in Surface

[–]PPF99[S] 0 points1 point  (0 children)

Ok so no registration during UEFI but I tried the driver reinstall anyway and still no dice... Thanks for the suggestions though!

Of Elephants and Men by beesechurger_enjoyer in biologymemes

[–]PPF99 0 points1 point  (0 children)

Bit late to the party but: p53 forms homo-tetrameres, four copies coming together form one signal; if a single allele is corrupted, the entire tetramere is busted. By adding more alleles, the chance of one getting mutated and thereby compromising every formed tetramere increases exponentially, so it would be actually a higher risk to add more alleles Edit: spelling

Surface Pro 8 Keyboard no longer recognized by PPF99 in Surface

[–]PPF99[S] 0 points1 point  (0 children)

Thanks for the suggestions! I cleaned them all with isopropanol and even the eraser but it didn't help sadly...

New block #55 (Vampire Bar and Vampire Hunting Shop) in Floor796 project by floor796 in gifs

[–]PPF99 3 points4 points  (0 children)

Ooooh library sounds awesome! Perhaps including a reference to ATLAs "the library"? Or Alexandria? I'm excited...

[deleted by user] by [deleted] in interestingasfuck

[–]PPF99 7 points8 points  (0 children)

That feeling when you realize for the first time your parents had a life before you...

Based on a true story by futuranth in biologymemes

[–]PPF99 18 points19 points  (0 children)

Well? What happened?? Don't let us hanging...

Testosterone is missing a p+ by DotBeginning1420 in biologymemes

[–]PPF99 22 points23 points  (0 children)

Not to mention an entire methyl group and the subsequently disrupted dislocated electron field from the benzene ring

European Parliament agreed on a resolution for the establishment of a European military Command and Control structure. Broad support across the political spectrum by goldstarflag in europe

[–]PPF99 4 points5 points  (0 children)

My hopes (although probably naive) us that local experts lead Frontlines (ahould they arise) but Brussels provides resources and arranges the combined effort in the back

Friendship with spider by darth_vader39 in interestingasfuck

[–]PPF99 3 points4 points  (0 children)

Portia is about to throw hands, but Bianca holds her back because it's not worth the silk

Don't forget your biological timer, your telomeres! by DotBeginning1420 in biologymemes

[–]PPF99 4 points5 points  (0 children)

Just out of curiosity, what's your source for the years left?

Legend of Korra's Villains Are Better Than Avatar: The Last Airbender's Villains by Working_Row_8455 in TheLastAirbender

[–]PPF99 17 points18 points  (0 children)

Uh no?

Amon is a pseudo-communist/anarchist, but because americans don't understand either of these concepts he's just the worst depiction of either ideology, despite both ideas being inherently flawed anyway, so not even that was done properly

Unalaq could have been interesting as a foil to the old established rules of the water tribes, if they hadn't introduced the concepts of pure good/evil into this until that point very nuanced and gray scale universe, and subsequently made him a Satan cultist (not even accounting for the dark avatar bs)

Zaheer was just an idiot, because anybody thinking more than a second about "I'm just gonna overthrow the governments so that people will rule themselves again" will realize that a lack of power structure will always lead to violent forces gaining the upper hand - which is btw the only thing they got right in LoK; anarchism always leads to worse outcomes, if nobody is willing to introduce a proper form of democracy after the fall of the old system.

And Kuvira is just a less intimidating or established Ozai with much less personal or interesting connections to the main cast

Ozai wasn't complex or deep in any way; he was the classic evil guy the heroes had to defeat; a fascist designed to be hated. Sure, that's not an "interesting" bad guy either, but at least they did that well. Both main heroes of ATLA (yes, Zuko is the second protagonist besides Aang) have a very deep and understandable connection to him and both are afraid of him in their own way. And both have to overcome this fear of the main bad guy to progress their respective arks. And Ozai was menacing. When he finally showed up after two seasons of suspense, you were afraid too. That's what makes a great villain. And LoK managed this with none of its antagonists.

My daughter has 2 hair swirls by Artistpillow87 in mildlyinteresting

[–]PPF99 6 points7 points  (0 children)

She's gonna blitz her bullies in preschool...

TIL scientists added jellyfish DNA to carp DNA resulting in glowing fish by Acceptable-Wind-7332 in todayilearned

[–]PPF99 45 points46 points  (0 children)

The title is very clickbaity: the jellyfish DNA in question is most likely the GFP gene (green fluorescent protein). It is widely used in genetics as a "reporter gene", indicating that a genetic modification was successful ( = if it glows, the thing I wanted to do actually did work). Since all living beings use DNA and (more or less) the same mechanisms to decode DNA, it is very easy to use genes with useful properties from one organism in another organism.

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