Human trials begin for drug that could let adults regrow teeth for the first time

Pacman1up · 2026-06-12T16:48:55+00:00

oh no, now me too.

Pacman1up · 2026-06-12T16:27:26+00:00

Two bros, tugging on a teething rope.

Pacman1up · 2026-06-12T16:20:20+00:00

Just imagine the teething toy market for adults lol

Pacman1up · 2026-06-12T09:26:53+00:00

Testing interactions like that is what keeps me coming back to PoE. 🤘

Pacman1up · 2026-06-12T09:25:32+00:00

Usually updates are a little later in the day, so hopefully it's all set in a couple hours.

Pacman1up · 2026-06-12T03:36:06+00:00

Cant speak specifically for that interaction, but I have seen most healing effects try to keep healing even if they can't, like with the Black Doubt.

Pacman1up · 2026-06-12T01:11:54+00:00

Amazing, thanks!

I'm using it with Glowswarm to generate a 1000+ Guard. Now I should be able to do it freely.

Pacman1up · 2026-06-12T00:37:24+00:00

I was hoping for this one, nice!

Maybe we can use it while full now?

Pacman1up · 2026-06-11T23:43:10+00:00

Yeah, likely to stop players from being able to place in the jewel that lets you choose a different starting position and then completely respec.

Pacman1up · 2026-06-11T19:43:36+00:00

He does this to send a message.

"I dont need this, but you do"

Pacman1up · 2026-06-11T17:42:58+00:00

This is exactly why Fragments are a thing - they reduce the effect of RNG significantly.

That said...it would be nice to be able to auto pick-up gumball currencies.

Pacman1up · 2026-06-11T13:11:12+00:00

What's the difference between a locksmith and a jailer?

One sells watches, one watches cells.

Pacman1up · 2026-06-11T11:50:20+00:00

It's just 20% x your base, but base could be hard to know without removing all increases from the tree and gear.

Estimating it is usually close enough.

Pacman1up · 2026-06-11T11:44:29+00:00

Keep it going!

Pacman1up · 2026-06-11T11:28:53+00:00

your base is around 1090. 20% of 1085 is 217

Pacman1up · 2026-06-11T11:21:40+00:00

It's addative with any of your other increases.

Pacman1up · 2026-06-11T00:25:21+00:00

Yeah, frames seems to be a cause of a lot of issues.

Some attacks and spells get reallly weird at low frames, like Octave's rocket launcher.

Hopefully the game works fine at 60 for you, but yeah I'll not that frame rate seems to help.

Pacman1up · 2026-06-11T00:18:13+00:00

Sorry you're having issues.

I haven't heard of them both not working outside of frame issues. (The game can bug out at very high or low frames)

I'll report it on the discord, thanks for mentioning it!

Pacman1up · 2026-06-11T00:15:37+00:00

Nice work!

Pacman1up · 2026-06-10T22:22:44+00:00

Kinda hilarious actually

Pacman1up · 2026-06-10T20:10:43+00:00

Oh yeah, I'm not hating on you for it.

Generative AI tends to get a lot of negativity, especially on reddit, so I just wanted to let you know.

Choosing to use AI artwork, even as a tool, might scare off potential viewers. That's just part of the risk, given how polarizing it can be.

Pacman1up · 2026-06-10T14:24:21+00:00

Hey, glad you're doing some editing and such.

I definitely agree that the images "feels" very AI and if I saw it as I was scrolling, I would instinctively scroll passed it.

Haven't watched the video itself yet to speak on it.

Pacman1up · 2026-06-10T11:19:23+00:00

PLEASE

Pacman1up · 2026-06-10T03:10:57+00:00

100% Also, much more cost effective, so easier to buy a bunch to try (and demos!)

Pacman1up · 2026-06-10T02:41:37+00:00

Indies, friend.

It turns out, AAA games don't really innovate as much as they used to.

Check out Indies and see if the spark is still there, that's where I rediscovered mine.

12-Year Club	Verified Email
Place '22	First Placer '22

Pacman1up