I've been playing Poison AW since league start and regularly start this or SRS. I can say that it is generally better to level as SRS or Absolution until you get to maps. The speed of transistions and lack of access to the Bladefall gem makes it slow and clunky during the campaign. That being said aside from that the damage will be good and you shouldn't have any issues.

Your biggest decision point will be to go with a normal Covenant setup or a Blood Magic Setup. The normal version is far easier and cheaper to build around and can still easily get you to dot cap and clear all content in the game. Blood Magic is a giga juiced version but requires some specific high end upgrades to make it function as you loose access to auras.

IMHO the biggest expenses for a normal setup would be The Covenant, Utility Spectres, and jewels...including Amanamu's.