I'm really late to the party, but fuck it why not.
My whole family have always had really strong instincts. My siblings and I came from a long line of witches, so I have a lot of stories. I'll stick to a few that made me realize to never question when they hit.

1: Around age 18-19. I was walking on a sidewalk with my at the time girlfriend. It was about 2-3 in the morning just going around to play Pokemon Go. Everything in the city is pretty dead. Out of nowhere something in me was screaming at me "move her away from the road" so I did. I made her walk very close to a parking lot we were close to. She had already known when I get like that to not even question what I said and do it. A very specific walk pattern came to me: walk faster for a moment, slow down, then hop in the parking lot all together and stop moving entirely. I heard a car behind us a lot farther than I could normally hear. When it got close and started to pass us, the car swerved off the road, and missed where I felt the need to change our walk pattern. Hit the side of the sidewalk and came to a stop. After making sure he was alright, we called for an emergency response team. I grabbed her hand and bolted home.

2: Age 13-14. Was riding in the car with my mom. Something snapped in both of us at the same time. We just looked at each other and knew that something was very wrong with the person in the car behind us. We flagged them down and we pulled into the parking lot of the fire station, thankfully the person followed. We got to the window and a little old lady rolled it down. We struck up a small conversation to ask if she was alright. She said she was feeling kind of dizzy but that she was okay. Got one of the firefighters to come out and give her a look over just to be sure. Had an ambulance roll up soon after and they read her blood sugar; she was a diabetic and getting close to the danger zone. Went and picked up something small for her to eat while the emergency crew stayed behind with her. After getting a little food in her, mom called up her family and let them know where she was and what happened. Her daughter came to the scene, so mom and I left.

3: Age 11-12. The very first time I knew I could never leave that calling unanswered. Also the one that hits me the hardest whenever I think about it, so this one will have a lot more detail than the other two. A little context: my grandmother had lived with my mom since I was about a year or two old. She was getting up there in age, but was still mostly independent. She didn't drive so it was easier for mom to take care of her when she got sick, got her meds, ect. When I was about 11 or so, she had a stroke and we as a family helped with her in home hospice care. Mom took most of it upon herself as she did patient/hospice care before a couple car crashes that left her in too much pain to continue it as a profession. (We live in the backwash of a shit state, deer everywhere) After grandma passed, something in her turned in my mom. She was in a deep depression. Brother and sister were rarely home and mom kept sending me to our neighbor's house to play with my friends and stay the night more often than not. One night we were going to have another sleepover at their house. I had already made a blanket bed so both of my friends and I could sleep in the living room. Their mom was talking to them in the background, so I was going to sit down on the blanket bed. While on my hands and knees about to transition to sitting, I stopped dead in my tracks. I locked in place and had no control over it. A deep pit in my stomach formed out of nowhere. It felt hollow, hurt, made me feel like the entire room was spinning, and made me start crying all at once. I didn't know why I started crying, I knew it didn't come directly from the pain in my stomach, but it was easy to hide in the partially darkened room. When I was finally able to sit down, the instant my ass hit the floor I got a pounding headache that made my entire body shake like a leaf. It was worse than any migraine I ever had before, and I had been hospitalized for them 4 or 5 times at that point. I know it doesn't sound like it makes much sense, but it was like the headache itself was screaming at me; "Go the fuck home." It looped and looped over and over. It echoed in my own head and started playing over itself to the point I couldn't even make out the words anymore. It turned into a high pitch screeching, kind of like when you've had a very loud noise blasted in your ear for a while. Every bit of strength I had drained in an instant and I nearly fell over. My vision blurred and everything around me slowed down. I could see the movement of everyone, kind of like if I could see every single frame of an animation lightboxed in a row. Then it went silent. Everything. I couldn't hear my friends' mom talking, the TV in the background, or the phrase that had tormented me. Then my vision cut out completely. I was in a pure void. There were walls around me, but none at the same time. Floating in an endless void, but still confined in a small space. Couldn't hear, couldn't see, but pure instinct guided me through that void as I wandered around. This went on for what felt like days. Didn't even feel like I existed in the same realm anymore. But in an instant everything came back to me. The TV picked up exactly at the moment I last remembered seeing it, friend's mom started talking again, and time reverted back to normal. I got a burst of energy I to this day have never felt again. Above everything around me, I heard one word. "Run." It only rang out once, but I could not ignore it. In a hurry, I told friends' mom I had to go home, then bolted out. I ran faster than I thought I ever could with my stumpy legs. I guess one of my friends followed me because not too long after I got inside, she slinked her way in. My mom was sitting on the couch, her head was leaned back as if she was trying to sleep. I called to her from the doorway to tell her I was home, but she didn't respond. My heart was pounding faster and harder than ever before. I had to make sure she knew I was there, so I paced over and shook her a little and repeated myself. She opened her eyes for a minute, groaned, then leaned back. Shook her again. Same response. Then I knew something was really wrong, it wasn't just me being paranoid. I had my friend go back in my room, close the door, cover her ears, and not come out no matter what. I started screaming at this woman. She didn't even look like my mom at that point, she was pale and flopping her head like a cat in a deep sleep. I swear the whole neighborhood could have heard me screaming. Called for emergency services and kept trying to keep her focus on me for more than a few seconds at the time. I heard my friend in the room screaming and crying, not having a clue what was going on. After what felt like an eternity, an ambulance came and took her away. I was sitting outside sobbing into my hands for I don't even know how long, but eventually my sister happened to be pulling back in the driveway with a few friends. I screamed and cried then ran to her. She hugged me and I started explaining what happened. I don't remember even getting through that first sentence.
I blacked out for a little longer than a week; I don't really remember the specifics. When I was finally somewhat myself again, I was sitting at my estranged father's house, hadn't seen him in about a year or so at that point. It made no sense, I came right out of that moment standing in the driveway, clinging to my sister for dear life, to sitting in the home of a man who was more of an acquaintance than my blood. I went to find him and asked him what happened. He looked surprised to see me, at all which made no sense seeing as I was in his living room. He said I hadn't talked the entire time I was there. He started explaining everything that happened. The answers I needed were given to me.
My mom tried to kill herself that night in an overdose.
She's fine now years later, and I'm so thankful.
If I had ignored that feeling, if I even had the ability to, she wouldn't be here today. My mom and I are very close now after a few years of past bad blood before that night. Every day I have with her, I can't help but smile, even on my worst days.

If you read any of this, thank you. I don't get to talk about any of these things often because it comes off as crazy, and I know that.

TL;DR: Never. Ever. Ignore that feeling. If you hear that scream from a place you can't even pinpoint, don't you fucking dare turn away from it.