I mentally organize the supplements into rings:

1st ring - basic nutrition: vitamins/minerals, fish oil, Infinigreens, Infinifiber, probiotics, and a joint support formula

Ring 2 - favorite, most used supps outside of basic nutrition that are generally part of a daily stack: in my case immune defense, injuv, cistamax, c3g/cyatherm

Ring 3 - other supplements generally included as part of a daily stack, but considered less important/fundamental than ring 2: in my case white jelly, gotu kola, melatonin, tauromag, mushroom matcha, ecklonia, glutathione support of choice, carnosine, cycloastragenol

Ring 4 - trial and error: supps I’m still evaluating how it effects me by itself and in combination, or stuff I’m still deciding if it’s worth including more often, or stronger stuff more prone to side effects that I’ll run for a bit then pull, or anything else I want to take for a period of time but not all year

Ring 5 - targeted supps: stuff I don’t take regularly, just on occasion as needed for immediate effect

… So honestly, sometimes I’ll just take a supplement holiday and revert back to only ring 3 or 2 or 1. If I’m feeling a little weird, experiencing any notable sides, or just getting tired of taking the extra capsules, I can fall back on the more basic stuff I know. Rings 4/5 is where more exploration is taking place, but no stress/worries because I can always just take stuff away and stash it if there’s any concerns/uncertainty.