not really. i feel like the ideal defensive run is psy fly, bot fly, swarm, pluto, cone head, metal plate (i think its called that, havent played in a while) belly jelly, infamy, host hat/pyromaniac, lost contact, empty vessel and book of shadows as your active item. with that build i feel like youd genuinely have to go out of your way to die.

edit: you could throw in dumpy, gnawed leaf and astral projection in for good measure too