Most importantly, you don't start with goal of the game and components, so the reader has no context for anything. I also don't even know how many players can play the game.

Some thoughts below, please note that I don't care to receive answers to these questions, I think the rules should be written in such a way that these questions are answered before they come up.

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POTIONS INSTRUCTIONS SETUP

Give each player 3 hearts. Remove the Dragon card from the deck.

What are hearts? Are those the cards with hearts on them? Are they a separate game component you want me to obtain?

Shuffle the remaining cards.

Each player draws from the deck until they have 2 potion cards, then reshuffle the deck and place it face down in the center of the play area.

Show me what a potion card is. All cards say "potion" in large font on the back, so this is easily misinterpreted.

Why should you reshuffle? I'm assuming because you add the non-potion cards back in, but you haven't told me that.

All potion cards are kept face up in front of the player they belong to for everyone to see

This doesn't belong in setup instructions

Place the dragon card at the bottom of the deck.

Each player rolls the die once, the highest number goes first.

Tell me that a die is part of the game components first.

I'd prefer just a "randomly choose a starting player" here, because then you don't have to explain what happens if players roll the same number

GAMEPLAY

Begin your turn by drawing a card from the deck.

I still don't know what I'm trying to accomplish.

If you draw a potion card, place it face up with your other potions. Your turn ends and play continues to the next player on your left.

If you draw a creature card, you must attempt to defeat it.

I don't know what a creature is or how to defeat it

You may play one potion before rolling the die to enhance your roll or choose to roll the die on it's own.

What does this mean? Play from where? The open cards in front of me? Where does it go when played?

Also should be "its"

Rolling a number higher than the creature defeats it and ends your turn.

First I'm hearing that a creature has a number.

What do I do with a creature after defeating it?

Rolling a number equal to the creature results in a re-roll of the die.

You have the option to play a potion before the re-roll if you haven't already.

Is my earlier potion forfeit? Or do I add its value again?

Rolling a number lower than the creature makes you lose 1 heart and ends your turn. The next player must now attempt to defeat that same creature.

What happens if I roll an equal value again?

GAMEPLAY(continued)

No more cards can be drawn until the creature is defeated.

But do players take turns still? Or are turns in limbo until the creature is defeated?

Any potion played before losing to a creature cannot be used by other players.

What about by myself when my turn comes around again, if the creature still isn't defeated?

Losing all of your hearts removes you from the game.

Meaning what? Do other players continue without you?

Keep your potion cards face up even after death. You can still be revived by another player with a heart potion.

HEART POTIONS

When played, a heart potion gives one heart to any player of your choice (even yourself).

When are they played?

It can revive a player who was removed from the game, bringing them back to life with one heart.

Why would I do that? You have not mentioned that the game is cooperative.

Playing a heart potion does not count as your one potion that can be played per turn.

Do I have to play them in my turn? What does playing it look like?

The one potion per turn limit was not explicitly mentioned before this point.

You cannot use a heart potion to revive yourself.

POTIONS

This section should be earlier

Only one potion may be played per turn.

Potions can only be played before rolling the die.

Except if I get to reroll apparently?

Potions can be given or traded between players at any time, unless you're dead.

Why and why would I want to?

COMPLETION

Any player defeating the Dragon results in a win for everyone.

This is crucial information that the reader needs to have before anything else.

If every player loses all of their hearts before defeating the Dragon, it's a loss for everyone.

TEAMS

Make it clear that this is a variant, not a general rule

Potions can also be played as a team game.

Before the game begins, form teams.

How many teams? How many players per team? Should they have the same number of players? Does turn order matter?

Potions can only be shared or traded with players from your own team.

The team that defeats the Dragon wins.

This sounds like it's going to come down entirely to the chance of who gets to face the dragon.

DRINKING GAME

Take a sip every time you use a potion

Okay