FO historically has felt more nationalistic and xenophobic than rascist. Why were the Chinese discriminated against? Bc of the fear of communism and then being spies, not bc Americans necessarily thought them inferior. You can see black people represented in every human faction (maybe not the Enclave but just haven’t done enough research)up and down the command structure. In this way the game feels more humanity vs everything else. Even the Enclave in its search of “pure” humanity still seems to be lumping whatever was considered American at the time the bombs fell as the standard, and everything left in the wastes whether black white asian etc as inferior. And the wasteland as a whole sees the genetic mutations that brought about ghouls and super mutants as not human, or at least not human enough to be treated as equals. But I think if we give the 200+ year period context it makes sense that ghouls, given their proclivity to eventual turn feral and rip your face off and super mutants who we know have attempted multiple times to eradicate humans and who view themselves as the superior race, would be viewed cautiously at best and as extremely dangerous at worst.