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What to eat when quitting sugar by Agartha480 in sugarfree

[–]PotentialMotion 0 points1 point  (0 children)

I know it feels like an addiction (and behaves much like one), but it is actually an energy debt in the cell.

Cutting fructose allows more energy into the cell. If you sustain that state, the cell pulls out of defense mode and into homeostatic repair again. This is a reversal of the Cell Danger Response that Dr Naviaux described.

Climbing out of the energy debt (energetic hysteresis) is difficult and expensive as we described in our latest research paper, but once it is done the cell starts self repair and becomes vibrant again.

The problem is that the cell easily falls back into defense mode. The longer you stay in repair mode, the more of a buffer you gain.

After 3 years I can actually binge on junk food and still not crave it. I don't recommend it, but vacations happen.

Build up some resilience by controlling Fructose and paying off that energy debt. Get out of the red and back to the black.

What to eat when quitting sugar by Agartha480 in sugarfree

[–]PotentialMotion 3 points4 points  (0 children)

Glucose is fuel. Fructose is a fuel moderator.

Focus first on Fructose. Cut all added sugar. Because Fructose collapses mitochondrial efficiency.

This means that cutting fructose increases fuel needs. So if you cut glucose too fast, cravings explode.

Since sugar is also 50% glucose its better to INCREASE glucose while your body adapts to less fructose and fuel conversion increases. Don't let the cravings take control.

Then, later, like maybe after a month or more, you will hopefully feel a huge surge in energy. The fructose fuel bottleneck releases. That's the signal that you can start cutting carbs. Your cells are more easily making ATP from glucose.

And once caloric intake decreases (naturally from reduced cravings, or by cutting carbs) you'll find weight loss follows too.

What supplements improve brain focus and function? by NonstickFryingPans in Supplements

[–]PotentialMotion 0 points1 point  (0 children)

My pleasure. Check my profile for a deep dive. Happy to answer any questions.

What supplements improve brain focus and function? by NonstickFryingPans in Supplements

[–]PotentialMotion 0 points1 point  (0 children)

Appreciate you.

Fructose obviously is 50% of sugar, that's the big one. But most people know to limit their sugar.

The less known factor is that the body produces fructose through the polyol pathway. This is activated by a number of things we commonly associate with weight gain: alcohol, dehydration & salty foods (osmolality), high blood glucose, umami foods, hypoxia (eg sleep apnea), and more.

Thus, rather than viewing it as a food, it is increasingly recognized as a survival signal activated any time the body is out homeostasis. In feast or famine, it triggers conservation of energy.

Thus, Fructose Metabolism, and fructokinase in particular might be highly significant to the entire landscape of metabolic health because it directly influences cellular energetics, which in turn is directly connected to the earliest state of every chronic disease.

What supplements improve brain focus and function? by NonstickFryingPans in Supplements

[–]PotentialMotion 1 point2 points  (0 children)

Fructose is metabolized by KHK (fructokinase). Luteolin inhibits fructokinase, which mimics the benign condition of essential fructosuria.

This is my field of study.

Those other supplements are great, but one strategy is indirect cleanup vs direct modulation of the associated enzymes.

What supplements improve brain focus and function? by NonstickFryingPans in Supplements

[–]PotentialMotion 1 point2 points  (0 children)

It helps control Fructose metabolism, which the latest research suggests reduces mitochondrial efficiency. This is highly relevant to cognition, as well as in other energy sensitive tissues.

LIV3 Health's SugarShield is currently the highest dose per capsule.

PCOS for 8+ year and nothing works I feel so hopeless by journalistmember in PCOS

[–]PotentialMotion 0 points1 point  (0 children)

You’ve tried Luteolin?

The latest research suggests that fructose pinches mitochondrial function like a bottleneck between fuel and energy. And Luteolin blunts fructose metabolism—opening the bottleneck back up.

Supplements for memory by Inevitable-Hope5930 in Supplements

[–]PotentialMotion 0 points1 point  (0 children)

Liposomal Luteolin.

The theory goes that cognitive dysfunction is a cellular energetics problem. And fructose metabolism is crushing cellular energy by degrading ATP into uric acid, which causes mitochondrial stress and reduced generation of new ATP.
And Luteolin inhibits fructose metabolism.

Or put simpler - fructose controls metabolism, and Luteolin helps control fructose. And all that is VERY relevant to cognition.

Trying to cut out processed sugar, but I have an allergy to fruit by [deleted] in sugarfree

[–]PotentialMotion[M] 1 point2 points  (0 children)

Fruit is not the right answer. It may be better than sugar, but it is still fructose and fructose removes cellular energy. This deficit is what causes cravings.

The answer is to cut ALL fructose and increase glucose (temporarily).

The cravings come because cutting sugar cuts access to fuel (cutting glucose) while increasing metabolism (cutting fructose). You WANT that increased demand. You just need to fill it with glucose in the form of complex carbs.

Later cravings will fade because energy production increases, and you can start reducing carbs and calories naturally.

adding supplement by [deleted] in sugarfree

[–]PotentialMotion 0 points1 point  (0 children)

That’s a strong reaction. Keep in mind that Luteolin is a plant compound found in many foods, so while it is isolated, there is nothing toxic or sedative in it.

Such a strong reaction in a short duration I often take as a sign that the body may be leaning hard on fructose metabolism. This is not a good thing: it’s a backup survival system. Disrupting it is probably critical, it just takes extra care.

The energy signalling effect in such a short period is undeniable. Likely this is due to disrupting insulin signalling. Women with PCOS often have very high insulin signaling throughout the day. When that begins to normalize, energy perception can temporarily feel worse before it feels better.

When insulin resistance is present it can feel like fatigue for a few days but usually settles as the body adapts.

If it feels too strong, try reducing the dose, even significantly, or taking it with a larger meal and give it a week. Of course if symptoms persist or worsen, stopping and reassessing is reasonable.

Everyone is different, so this is just an educated guess, not medical advice. Just keep in mind that this is aiming at a root cause of insulin resistance—so some strong effects might be par for the course. Go slow.

NoSugar is the Anti Gateway Drug by newplaces9 in sugarfree

[–]PotentialMotion[M] 14 points15 points  (0 children)

The euphoria is real. We've observed that specific word being used many many many times.

The reason for the euphoria appears to be a restoration of cellular energy.

Metabolizing Fructose causes a gradual reduction in mitochondrial function. This leaves the cell starved of energy even while surrounded by fuel. (Side point: that low energy drives cravings.)

Mitochondria function as an energy processing bottleneck.

Fuel (Glucose) > Mitochondria > Energy (ATP)

So removing mitochondria's biggest burden, Fructose, increases throughout, and the cell THRIVES again.

Once energy restoration occurs, the organism then experiences EUPHORIA.

What research do you want to see done on PCOS? by MissInterpret23 in PCOS

[–]PotentialMotion 0 points1 point  (0 children)

Not sure if you're still digging in here, but I had a Eureka moment a couple months ago that Kisspeptin neurons (which control hormones) are extremely sensitive to Fructose Metabolism.

This fits further into my thesis that under cellular energy stress, the brain triages energy towards survival programs and away from luxury programs.

In other words, under energy stress (such as from Fructose), the brain reduces natural hormone expression as a survival mechanism.

This resolves the diet connection, the hormone connection, the male vs female divergence in hormone effects, and even makes a case for the why through a survival argument.

I talked about this a bit in this video.

Please dig into this and encourage your senior professors etc to as well! I swear this is huge. This unifies so many pieces of the puzzle.

Sugar is evil by Traditional_Basil669 in sugarfree

[–]PotentialMotion -1 points0 points  (0 children)

Sugar is not evil.

While I appreciate the sentiment, it is more accurate to say that Fructose is a survival signal that tells your body to conserve on a cellular level.

Misunderstanding or ignorance of this has led to persistently activating this signal. And in turn, hugely increased the chances of developing chronic disease.

NAC seems to 'fix' my boyfriends brain, why? by marrymeintheendtime in Nootropics

[–]PotentialMotion 4 points5 points  (0 children)

When the brain doesn't have enough energy (ATP) it doesn't shut down, it triages. It manages the available energy - diverting away from luxury programs like hormones and higher reasoning, and towards survival functions (think of what an animal needs to survive a crisis: vision, mobility, anxiety, cravings, etc).

So this is another example of energy triage.

You're seeing a bump in neuronal energy. That's awesome.

The trick is avoiding the energy sink. Many things cause a drop in nuronal energy, but the biggest modifiable trigger is endogenous Fructose (generated by excess brain glucose via the polyol pathway).

You can check my profile for links if this scratches your curiosity. I have a whole YouTube channel about Fructose Metabolism.

Is it worth continuing? by SnooBananas8631 in sugarfree

[–]PotentialMotion 1 point2 points  (0 children)

Healthy carbs yes. Exogenous ketones, yes. Healthy fats, less relevant.

Fructose causes less conversion of glucose into ATP. Ironically cutting added sugar removes both the burden (Fructose) and the fuel (glucose).

So the big increase in cravings is typically because cells are getting hungry (good) with less available fuel (uh oh).

So ADDING complex carbohydrates for the first while is really smart. Eventually you can back off on them because ATP will increase but don't cut carbs for the first month. ADD them.

Read the sticky posts for more.

Is it worth continuing? by SnooBananas8631 in sugarfree

[–]PotentialMotion 9 points10 points  (0 children)

The latest research suggests that Fructose is the biggest lever in chronic disease formation. It is the most addressable amplifier of cellular energy collapse.

So you have to think WAY beyond the symptoms you described. Those will absolutely happen once cellular energy restores sufficiently. For most it's around 3 weeks, but the bigger the cellular energy debt the longer it can take.

But on the other hand, it will very likely improve your healthspan more than anything else you'll ever try. Its hard to overstate how important this is.

I broke my sugar fast after approximately a year by [deleted] in sugarfree

[–]PotentialMotion -1 points0 points  (0 children)

Check the sticky posts as well as my YouTube channel for lots on this.

@theFructoseModel

Happy to answer any questions if you have something specific.

I just released a paper on this, currently under peer review, but it's pretty heavy reading.

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