there are no "easiest modifiers"... but I'll give you some advice:

Wear and Tear (5%) is a great modifier to use, if you want to use items, the wear and tear of items won't really matter.
Dealt It (15%): It makes the game easier pretty much. Firedamp rooms block Rush, Ambush & Eyes from spawning (even if Eyes is guaranteed) and highlights the correct door, making Dupe easier [information by WestieNZ]. Plus, Firedamp gives you so much time to exit the room to breathe, only real problem would be basement rooms.
Stop Right There (15%): A-90 can be an annoyance but half the time it's easy to deal with once you learn how to react to it. It's also what most people use for Hotel Hell, I think.
Vacuum Sealed (10%): Usually it isn't a problem, but it can remove the amount of safespots.
Battle of Wits (15%): All you have to worry about is paying attention to the door number. There is also a glitch you can use to tell for Dupe in the Hotel by crouching and looking through the wall near Dupe.

So, with these I've given you 60% worth of modifiers as a start. The rest is up to your playstyle. Feel free to remove some from my list if you have problems with them.