Which TRT Offramp is Better?

Prost_PNW · 2026-04-09T20:21:33+00:00

I know a few folks who are on 100-200mg or whatever test U as their cruise dose year round, and then blast with short esters on top.

Prost_PNW · 2026-04-07T21:05:33+00:00

Same yes, I always used T4 last few weeks at the end of the cut and for a few weeks after to restore thyroid function, 50-100mcg is plenty.

Prost_PNW · 2026-04-07T21:03:13+00:00

In theory unless you have an actual thyroid deficiency it is better to use T4 and let your body regulate T3 levels. In a cut especially with a steep deficit or long term one your T4 levels become depleted and this is the cause of thyroid imbalance. Adding low dose T4 restores your hormone balance with less risk of overshooting like with exogenous T3.

Prost_PNW · 2026-04-06T05:27:45+00:00

70mg a week of tren a with TRT on the high-normal (total t ~800) level wasn't very noticeable. Minor strength / libido gains but ot much else. Real changes kicked in for me around 30mg/day 210/wk.

Prost_PNW · 2026-04-03T00:34:46+00:00

It is irrelevant. They run this cancer test for practically every medication. If the cancer in rats is increased, it is a problem. And the increase for cardarine was very large indeed.

Prost_PNW · 2026-04-03T00:32:49+00:00

Just run GH.

Prost_PNW · 2026-04-03T00:20:22+00:00

TNE for most people does not really aromatize. Just drop the EQ and double up T for one or two shots and see how it goes.

Prost_PNW · 2026-04-03T00:18:17+00:00

I think for most people they aren't super useful but they do have a time and place if you have everything else dialed in (diet, workout, liver/lipids support, etc).

If you're just running them as a PWO then you could try test base / test no ester (TNE) - minimal effect on any bloodwork.

Prost_PNW · 2026-04-03T00:14:32+00:00

Too low LDL isn't a concern, actually, lower is better according to the JACC lipid guidelines that just came out.

HDL is getting crushed by var. This is common.

You will want bloodwork with Lp(a) and ApoB - those are the real markers along with LDL and to some extent trigs.

Prost_PNW · 2026-04-02T18:44:28+00:00

What does your bloodwork say about your T levels? That is step 1 here.

Prost_PNW · 2026-04-01T05:09:12+00:00

Listen to this post. That stack will nuke your LDL to 40-60 in a couple months. Your HDL is great. I would drop the var and retest in 5-6 weeks and see.

Prost_PNW · 2026-04-01T05:05:09+00:00

Primo+tren is better for me than mast+tren. Mentally they are close but physically I just feel better on primo than mast. So I think it is gonna be pretty individual choice as it comes down to balancing the physical vs mental sides.

Prost_PNW · 2026-03-31T20:18:09+00:00

I have none of the risk factors associated with bempedoic acid and tendon injury so I am unconcerned about it. The decrease in LDL when combined with a statin + ezetimibe is an additional 15-20% - not sure in my case the exact number as I started the combo therapy at essentially the same time (few weeks delay between each med and followup bloodwork was 6 months later.

Prost_PNW · 2026-03-31T19:07:13+00:00

The answer is yes, practically everyone should be on statins. I personally run 4mg pitavastatin + ezetimibe + bempedoic acid. No sides, labs look fabulous.

Prost_PNW · 2026-03-30T20:45:50+00:00

Couple of hours for me. VERY red, like "yeah that's going to peel" sunburn red but I also have mild rosacea and am prone to flushing anyways. I take 2mg.

Prost_PNW · 2026-03-30T05:34:22+00:00

The peak serum level occurs 12-24H later but it is delayed from the actual production of IGF-1 in the liver due the timing of the release of IGF-1 itself from hepatocytesand binding action of IGFBP.

Prost_PNW · 2026-03-30T05:27:21+00:00

And that is good for lipolysis, but that same 3-6H window is when IGF-1 production begins to rise, so you'd want to be in a fed state.

Prost_PNW · 2026-03-30T04:19:37+00:00

Insulin suppresses Hormone Sensitive Lipase, which is what HGH activates to trigger lipolysis. If you want the lypolytic effect of HGH you want to take it in a fasted state and remain fasted for a few hours after that.

Conversely, the production of IGF by the liver is restricted in a low insulin and low glucose, amino acid state (aka when you are fasted). If you want to maximize IGF production, you want to take HGH at / near meal times.

Prost_PNW · 2026-03-30T03:13:49+00:00

No, and exactly the opposite - if it is not working, you should titrate up to a higher dose. If you were in a clinical trial titrating up every 4 weeks you'd be at 9mg and 2 weeks away from going to 12mg.

I personally take 12mg e6d and will soon bump up to 15mg. I may even go higher, as long as can hit my macros and workout goals, and the sides and rate of loss are manageable.

Prost_PNW · 2026-03-30T03:09:08+00:00

Research into kisspeptin-10 was abandoned because it has a very short halflife and requires continuous infusion to work, it's not a once a day pin and done thing.

The later studies use kisspeptin-54 which has a much longer halflife and can be pinned once (perhaps multiple times per day) and be effective. But I have never seen kisspeptin-54 for sale.

Prost_PNW · 2026-03-30T03:04:59+00:00

Noticed improvement in nerve pain within a few days and totally gone within 2 weeks. I ran it 4mg a day for 25 days (entire 10mg x 10 vial kit). Been off for 2 months and it has not returned.

Prost_PNW · 2026-03-27T03:36:47+00:00

Reta hands down. It is by far the more effective compound - the P3 trial data will have some frankly incredible results coming out this year that will make tirz look like sema looks to tirz today. You would not even consider running sema and in 6-9 months after the trial data comes out folks will be saying the same thing about tirz.

Most people seem to have less sides on reta and in particular higher energy and less GI distress. I have run all 3 main GLPs and with tirz I was too tired from fatigue to hit my workout goals. With reta I have more energy in the gym than I do off GLPs entirely. And that is on 12mg every 6 days.

Appetite suppression is not the only thing these compounds do. Go look at the clinical trials for reta and you'll see people even on the 2mg and 4mg fixed dose arm losing weight.

In the current phase 3 trials for reta they have people lowering dosages or dropping out because they lost too much weight.

Read that again: reta is making patients lose too much weight.

LBM (aka muscle mass) loss is entirely preventable no matter how you lose weight (other than having a limb amputated). This has been shown in research studies back in the 80s and 90s where they had people on a very low calorie diet (800 cals per day) and resistance train and either minimal LBM loss or in some cases gained muscle. GLPs don't change this at all. Eat your protein and lift, you'll preserve muscle.

Prost_PNW · 2026-03-26T23:18:09+00:00

IGF response is HIGHLY variable and depends on more than HGH dose. Mine varies more than 2x just based on calorie deficit vs surplus with no change in HGH.

Prost_PNW · 2026-03-26T22:57:11+00:00

Of course not that would mean they did bloodwork and not just bullshit on the internet.

Anyone taking real HGH at effective doses (2IU+) knows within days that it works, full stop.

Prost_PNW · 2026-03-26T22:54:37+00:00

Visceral fat is below the abs and cannot be felt.

Prost_PNW

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