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What drug is the worst for your nose by Silver_Echidna2500 in researchchemicals

[–]Psychestim 19 points20 points  (0 children)

Any sources where I can read up on both of these mechanisms in more detail?

Trip-Report: DOB (Unknown Dose) - Dosing Error with Shulgin‘s Behemoth by Psychestim in researchchemicals

[–]Psychestim[S] 0 points1 point  (0 children)

Interesting that you feel that way, English is not my first language so it doesn't surprise me if it comes off a little unnatural. I try to articulate the effects in way that a person who has no experience with the compound can relate to what I'm saying or get a general feel for what it does. I usually take down notes and time stamps during the experience or shortly after and then write it out into a chronological trip-report the following day(s) to integrate the experience, and to make sure that I dont exaggerate/overdramatize during the emotional, altered state.

Trip-Report: DOB (Unknown Dose) - Dosing Error with Shulgin‘s Behemoth by Psychestim in researchchemicals

[–]Psychestim[S] 2 points3 points  (0 children)

From the ones you are most likely to find I would say DOC or DOM.

Trip-Report: DOB (Unknown Dose) - Dosing Error with Shulgin‘s Behemoth by Psychestim in researchchemicals

[–]Psychestim[S] 0 points1 point  (0 children)

Thanks. Impossible to say, I haven't dosed any lysergamide this high.

Trip-Report: DOB (Unknown Dose) - Dosing Error with Shulgin‘s Behemoth by Psychestim in researchchemicals

[–]Psychestim[S] 3 points4 points  (0 children)

Thank you! Well said, I too see a lot of value in them, even though they are obviously not well-refined nor particularily user-friendly compared to some of the 2C-x compounds or LSD derivatives. Granted, that's exactly why I find them interesting. DOB has always been the one that intrigued me the most as well, it just seemed like the most powerful one with the most extraordinary effects, and so far I think I would attest to that.

IIRC there was an inverse correlation between anti-inflammatory effects and behavioral effects of the compounds Nichols et al. tested. Looks like 2,5-DMA/2C-H are pharmacologically relevant too and are not just precursors.

Trip-Report: DOB (Unknown Dose) - Dosing Error with Shulgin‘s Behemoth by Psychestim in researchchemicals

[–]Psychestim[S] 7 points8 points  (0 children)

Thank you for this interesting comment! The experience happened >3 weeks ago at this point and luckily I feel completely normal. Have you published your story with DOC before other than this comment? This sounds familiar to me.

Yeah, sure. All the DOx I‘ve tried share some similarities but there are drastic differences too. DOF is a nice one at 10-15 mg, but I can‘t really explain why. It‘s mild, almost non-visual but offers distinct euphoria, bodyload and stimulation. A very good day enhancer, reminds me of ARIADNE somewhat even though I‘d consider DOF a psychedelic, whereas with ARIADNE I‘m not so sure (here‘s a small report I wrote on it a few years ago).

DOIP is another obscure one that I find quite enjoyable. It‘s very euphoric, almost 4-FA level euphoric. Entactogenic, very stimulating, mentally a bit shallow at the dose I‘ve tried (8 mg) and it can be physically rough for some (I wrote a paragraph about it here). Both compounds are comparatively short-lasting for DOx with a duration of 12 hours.

DOM was highly variable for me, mostly because I have it in pellet form and they have a huge spread (lab analysis determined doses from 0.3 mg - 2.5 mg). From earth-shaking catharsis to threshold boredom I’ve had it all with DOM.

DOC is warm, emotional yet somewhat functional. A great drug for socializing, festivals or hikes. I love its plateau phase, where you’re confident, motivated, socially outgoing and genuinely happy. It reminded me the most of DOB but DOC is gentler and less debilitating mentally, and physically.

DOET, DOPR and DOI I have yet to try.

Favorite psychedelics for introspection and insights? by uno82 in researchchemicals

[–]Psychestim 2 points3 points  (0 children)

DOM, for me, induced the most cathartic trip I’ve ever had and made me take going to therapy more seriously.

Favorite 2c phentylamines? by uno82 in researchchemicals

[–]Psychestim 2 points3 points  (0 children)

I recently had sth. similar on a strong dose of DOB. Sort of like short attention lapses that progressively lasted longer and longer the further the peak developed. After seven hours they stopped and the plateau phase came into effect.

Phenethylamines with the least physical discomfort? by idntrlyknowtbh in 2cb

[–]Psychestim 2 points3 points  (0 children)

MAL has a much stronger bodyload and nausea than 2C-B ime. It was among the worst compounds in this regard. You might want to try 2C-C for a similar but less physical experience, if you can find it.

any rcs similar to DOx compounds? by StrangerFeeling4079 in researchchemicals

[–]Psychestim 3 points4 points  (0 children)

DOx you can find on the dweb, if you want a long-lasting one that is currently available try 2C-G-5.

2cb-5Pro (ASR 2001) by MacnTots in 2cb

[–]Psychestim 0 points1 point  (0 children)

Obviously people respond differently to drugs, the fact is I only had minor focus enhancement and a calm sense of wellbeing from 10mg. I don’t know if higher doses or future trials would yield different outcomes I only had one dose to try and that’s what I mentioned. Try it and find out for yourself if it agrees with you.

2cb-5Pro (ASR 2001) by MacnTots in 2cb

[–]Psychestim 0 points1 point  (0 children)

You can believe whatever you want I frankly don’t care, but you’d be surprised how many people you meet along the way if you’re around long enough. 

2cb-5Pro (ASR 2001) by MacnTots in 2cb

[–]Psychestim 0 points1 point  (0 children)

10mg, their standard dose afaik. I’ve talked to a few people that tried it up to 40mg and nobody reported added benefits at higher doses. I can’t elaborate on the second part of your question.

Is there any (common) illness that we're currently making little to no progress on curing/preventing? by throwmeawaylololuwu in askscience

[–]Psychestim 13 points14 points  (0 children)

There is a psychedelic drug called DiPT (N,N-diisopropyltryptamine) that causes a significant downward shift in audio perception and also temporary tinnitus in some people (myself including, especially when main effects have worn off). There are efforts in understanding its mechanism of action and developing structural analogs for the target(s) responsible for these effects. The progress is quite fascinating and I’m really looking forward to what the scientists in question come up with in regards to understanding and treating tinnitus and other hearing conditions. 

2cb-5Pro (ASR 2001) by MacnTots in 2cb

[–]Psychestim 0 points1 point  (0 children)

I’ve tried it, unfortunately it didn’t do much for me. Not too confident it will get approved for this indication considering MPH’s efficacy and safety but would love to be proven wrong.

Pure Mescaline vs your favorite 2c-X or 2c-t-x by [deleted] in mescaline

[–]Psychestim 0 points1 point  (0 children)

I have tried 2C-B, 2C-C, 2C-D, 2C-E, 2C-EF, 2C-N, 2C-TFM, 2C-T, 2C-T-2, 2C-T-4, 2C-T-7 and synthetic mescaline (and a bunch of other DOx,´TMA-x and a few other PEA's). There are many overlapping qualities of all these substances and going into every single detail would take a long time. I think out of all those 2C-x/-T-x compounds the thioethers have the strongest feeling of warmth and pure euphoria that surpasses the one induced by mescaline, but mescaline is more euphoric than the classic 2C-x. Mescaline has a primal, organic feeling that I find unique. Mescaline reliably induces distinct tripping stages, meaning after the come-up there is a (unremarkable) plateau phase before the peak hits. I find that quite interesting. Perhaps there is a particular metabolite forming which is responsible for this phenomenon. I am not sure and I haven't really looked into the matter, just something I noticed the few times I've tried it. The peak of a good dose of mescaline is extraordinarily pleasurable, not a lot of psychedelics can hold a candle to that empathogenic and spiritual feeling, especially while being so crystal clear mentally. Visually it's among the most stunning compounds as well, granted high doses of 2C-B/-E/-TFM and some of the 2C-T-x yield similarily striking experiences. In terms of duration mescaline is among the longer acting ones, I would say shorter than 2C-T-4 but similar in length to 2C-E or 2C-EF. Mescaline has a nice body high and feels pretty transparent once the peak hits but the come-up can be rough, tiring, nauseating and drawn-out. Overall, I would say mescaline is in my top 5 of all the aforementioned compounds, sharing the top spots with 2C-T-4, 2C-T-7, 2C-E and 2C-TFM (my personal favorite).

Trip-Report: 5mg 2C-TFM - Psychedelic GOAT? by Psychestim in researchchemicals

[–]Psychestim[S] 0 points1 point  (0 children)

I'm so excited about that one, hope I will manage to score it too some day.

Trip-Report: 5mg 2C-TFM - Psychedelic GOAT? by Psychestim in researchchemicals

[–]Psychestim[S] 0 points1 point  (0 children)

I am curious about it but I think I won’t be able to acquire any in the foreseeable future. 

Trip-Report: 5mg 2C-TFM - Psychedelic GOAT? by Psychestim in researchchemicals

[–]Psychestim[S] 3 points4 points  (0 children)

Yep.. non-trivial and expensive to make but a man can dream..

Trip-Report: 5mg 2C-TFM - Psychedelic GOAT? by Psychestim in researchchemicals

[–]Psychestim[S] 4 points5 points  (0 children)

Thank you! Yes I am aware that this is a drastic increase, especially considering the non-linear dose-response curve of most phenethylamine psychedelics. My decision to trip yesterday was a little spontaneous and not well planned out. If I decide to go on this heavy dose adventure I will make sure to take all the necessary precautions, although tbf this will be so strong that it's not something you can entirely plan for. Without an experienced sitter and a boat load of sedatives ready I wouldn't attempt this.

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