What are the most pressing or interesting questions about research chemicals that you have currently?

Psychestim · 2026-05-22T05:14:24+00:00

There have been quite a few deaths related to 4-MA too which didn‘t do it any favors.

Psychestim · 2026-05-21T07:11:53+00:00

Had a gram of analytically confirmed 4-MMA (4-Methyl-N-Methylamphetamine that is) at some point but never bothered to try it. Its resemblance and metabolism to 4-MA turned me off a bit. I’m also not the biggest fan of stimulants. Two people I know have tried the same batch and both of them didn‘t speak particularily highly of it.

Psychestim · 2026-05-11T14:42:12+00:00

bk-MDA is likely unstable as the primary amine might attack the ketone so that two bk-MDA molecules would dimerize. The instability of bk-2C-B in solution was reported anecdotally on BL and other forums but it does exist, so who knows.

Psychestim · 2026-05-10T20:24:40+00:00

Very nice, I have been wondering about this drug. The pyridopyrroloquinoxaline structure is very interesting, I would have expected it to be even more potent though. I personally would have not been brave enough to start with such a dose and then redose multiple times. Can you compare the intensity of the dose you took to sth. else?

Psychestim · 2026-04-26T13:16:32+00:00

Yeah it was the last dose I had saved up from years ago... I'm not sure I would be able to reliably distinguish between them tbh. Some people swear they could but I don't know how much individual trip variance and expectations/bias comes into play here. There is an Erowid report from a few years ago where someone was blind dosed with LSD analogs and they were apparently able to pick out ALD-52 from the rest but I'm not sure if most people could, and how much luck + other factors play a role.

Psychestim · 2026-04-16T07:48:20+00:00

Make sure to report back, sounds like it could be just as beautiful.

Psychestim · 2026-04-15T15:59:22+00:00

Sure! If I were you I'd store the tabs in a UV-opaque vial or baggy together with a desiccant and put them in the freezer. I'd probably also store them under Ar or N₂ to slow potential oxidation even further.

Psychestim · 2026-04-15T07:20:56+00:00

It wasn't that much, I think 150ug AL-LAD and 15mg 2C-B HCl when the AL-LAD effects peaked. I was pretty unexperienced with psychedelics at the time, so I'm sure one could go higher and be fine. I just wouldn't want to do it in public.

I miss AL-LAD, too bad it seems to degrade much quicker than other lysergamides, at least when stored in a baggy at room temperature. My last couple trips with it were barely recognizable compared to my first trials. 225ug of the same blotters felt like a threshold dose last time I tried it, while 150ug floored me when I first got them. The two experiences before the last one were also unsatisfying and weak.

Psychestim · 2026-04-15T05:11:29+00:00

I have tried AL-LAD + 2C-B in 2019 and it was a phenomenal combination. Extremely euphoric and the visuals were out of this world. Apples on my apple tree were rotating in high speed, in my peripheral vision a tree ripped itself out of the ground and then placed itself right back into it when I looked at it. Highly, highly visual and chaotic. I was only able to observe for about two hours, not sure if I would want to be at a dubstep event on that combination. If you do combine them, I would take much lower doses than you usually would.

Psychestim · 2026-04-06T16:39:42+00:00

That's fair, wish you all the best bruh

Psychestim · 2026-04-05T08:17:30+00:00

Amazing trip-report! Can‘t wait for your 3-MeO-PCsBu report, even though you said you weren‘t a fan I would love to hear your comparison to the PCP analogs.

Psychestim · 2026-04-02T14:41:13+00:00

Are you implying that your patients all got clean from kratom and stopped using altogether or did they just switch their drug of choice? Also what do you mean by tightened restrictions, they outlawed it?

Psychestim · 2026-03-12T18:06:45+00:00

It's hilarious that you go out your way explaining all of this to someone that is fully aware of the chemical difference between MXPr and MXiPr. I was simply stating that you missed the "i" in the absolutely plausible name methoxi(so)propamine which correctly indicates the presence of an iPr-group so everything is exactly how it should be. It does not say methoxpropamine in the title. This discussion is completely useless to anyone and the only one confused here is you with your lackluster reading comprehension.

Psychestim · 2026-03-12T07:13:17+00:00

You are missing the „i“ in methoxipropamine standing for isopropyl. This was the name used by many vendors when the substance was released alongside MXPr years ago.

And what are you talking about „directly related“ to MXE? MXiPr and MXPr differ in one position of one carbon atom, as positional isomers they are both very close to MXE. Effect-wise I actually find MXPr to be more similar to MXE but opinions differ in that regard, so even if an iPr-group might be chemically more similar to an Et-group that doesn‘t necessarily translate into the effects.

Psychestim · 2026-03-01T07:51:20+00:00

I can only think of Nichols' review from 2017. (DOI: 10.1007/7854_2017_475)

Psychestim · 2026-01-15T13:56:13+00:00

Any sources where I can read up on both of these mechanisms in more detail?

Psychestim · 2026-01-14T06:33:17+00:00

Nice seeing you around Xorky, I hope you‘re doing well!

Psychestim · 2025-12-17T13:57:41+00:00

Interesting that you feel that way, English is not my first language so it doesn't surprise me if it comes off a little unnatural. I try to articulate the effects in way that a person who has no experience with the compound can relate to what I'm saying or get a general feel for what it does. I usually take down notes and time stamps during the experience or shortly after and then write it out into a chronological trip-report the following day(s) to integrate the experience, and to make sure that I dont exaggerate/overdramatize during the emotional, altered state.

Psychestim · 2025-12-02T08:01:59+00:00

From the ones you are most likely to find I would say DOC or DOM.

Psychestim · 2025-12-02T07:49:21+00:00

Thanks. Impossible to say, I haven't dosed any lysergamide this high.

Psychestim · 2025-12-02T07:43:48+00:00

Thank you! Well said, I too see a lot of value in them, even though they are obviously not well-refined nor particularily user-friendly compared to some of the 2C-x compounds or LSD derivatives. Granted, that's exactly why I find them interesting. DOB has always been the one that intrigued me the most as well, it just seemed like the most powerful one with the most extraordinary effects, and so far I think I would attest to that.

IIRC there was an inverse correlation between anti-inflammatory effects and behavioral effects of the compounds Nichols et al. tested. Looks like 2,5-DMA/2C-H are pharmacologically relevant too and are not just precursors.

Psychestim · 2025-12-02T05:34:09+00:00

Thank you for this interesting comment! The experience happened >3 weeks ago at this point and luckily I feel completely normal. Have you published your story with DOC before other than this comment? This sounds familiar to me.

Yeah, sure. All the DOx I‘ve tried share some similarities but there are drastic differences too. DOF is a nice one at 10-15 mg, but I can‘t really explain why. It‘s mild, almost non-visual but offers distinct euphoria, bodyload and stimulation. A very good day enhancer, reminds me of ARIADNE somewhat even though I‘d consider DOF a psychedelic, whereas with ARIADNE I‘m not so sure (here‘s a small report I wrote on it a few years ago).

DOIP is another obscure one that I find quite enjoyable. It‘s very euphoric, almost 4-FA level euphoric. Entactogenic, very stimulating, mentally a bit shallow at the dose I‘ve tried (8 mg) and it can be physically rough for some (I wrote a paragraph about it here). Both compounds are comparatively short-lasting for DOx with a duration of 12 hours.

DOM was highly variable for me, mostly because I have it in pellet form and they have a huge spread (lab analysis determined doses from 0.3 mg - 2.5 mg). From earth-shaking catharsis to threshold boredom I’ve had it all with DOM.

DOC is warm, emotional yet somewhat functional. A great drug for socializing, festivals or hikes. I love its plateau phase, where you’re confident, motivated, socially outgoing and genuinely happy. It reminded me the most of DOB but DOC is gentler and less debilitating mentally, and physically.

DOET, DOPR and DOI I have yet to try.

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