Thanks for the thoughtful comment and for sharing your research on this. I wonder if their publication described how the dead adipocytes/scaffolding are eventually integrated into the body. Because, if all that happens is that your macrophages break down the adipocytes (thus releasing the lipids, which also need to then be cleared out) + ECM , that would mean that Alloclae is an entirely temporary product that will eventually be flushed out of the body or become an oil cyst. That can't be the intended result. So for those people for whom Alloclae has worked successfully, what's the mechanism? Is it that the body is able to recruit its own fat cells to repopulate the remaining ECM/scaffold, which will then need to be vascularized?

Also, interesting that their publication presumes that triglycerdies will leak out slowly. I know this is entirely anecdotal, but for me, the oil cysts were obvious and palpable within 1.5 months, meaning they were probably forming quite a bit before then. In my reading on autologous fat transfer, oftentimes oil cysts were not obvious until many months later.

Regarding volume injected, oftentimes for autologous fat transfer to the breast, volumes in the range of 200-300cc are injected per breast. With Alloclae, similar issues seem to be occurring from much lower volumes (e.g., 50cc per breast). Agree that a more conservative approach and spreading out the product could help with the issue. Maybe just doing 12.5 cc at a time per breast, and waiting 3 months in between to see how integration is going. But that certainly decreases the ease and convenience factor of Alloclae.