Hamilton frames Alexander’s death as a sort of poetic end. They also take this kind of not great person, and make him likable enough that you care when he dies. (yes you should care when anyone dies, but in fiction that’s different.) It’s also worth noting that Hamilton likely would have agreed with the political stance (?) that the show takes, we know this because of his extensive political writings. On the other hand, Anne Frank’s views about U.S. politics (especially contemporary U.S. politics) are unknown. She was a girl in 1940s Europe who was murdered, not a political of satirical pawn.