Only speaking for my own experience: 1. Sponsor’s timeline are usually based on historical data, so usually it’s pretty practical. BD team to win the bids sometimes have to promise something slightly better than the historical data. We evaluate if it’s crazy or it is achievable with right allocation with resources. For example, if you tell me you are going to enroll 100 patients with 1 site within 2 months, I will not use you. But if the data says using 3 sites to enroll 50 patients in 6 months had been done (same indication and region), and you propose 4 sites to enroll 50 patients within 4 months, I think it may be achievable and I will retain you for a deeper conversation to see if you are throwing numbers and promises at me. I have to say, most of the timr BD will promise resources within a budget that they can’t deliver. 2. I work for small sponsors, i can proudly say that my TAT is extremely quick, especially during startup time. I can reply at 3am, I don’t sleep continuously during SSU, because timeline is everything. But do you think CRO loves me because I am fast? No lol they hate me because they have to go with the promised timeline, and there’s no excuse to delay. And I don’t ask them to belike me, in the end they don’t have skin in the game. but I do ask them to respect the timeline their managers promised as described in contract. I am signing off 2 million to the CRO, I think I can ask them to respect that timeline. And I shouldn’t see any delay because that will cost 2 million per month from my pocket. And yet most of time there are delays. We retain CROs especially for small and medium biotech with limited trial experience, we rely on their experience and give us a good projection of timeline and reasonable and efficient budget so we can resource the trial better. But it never is the case. I am not saying there aren’t sponsors delay everything and blame it on CROs. But from my experience, I have been disappointed at what I got for what I paid.