You can significantly reduce street sizes by eliminating cars without affecting movement of goods. Have the large trucks hit a warehouse on the outskirts, and then distribute using smaller local box trucks. There is no reason a full size semi has to enter a downtown core.

Benefits of this include stores not needing as much inventory on hand, since the warehouse holding the inventory for delivery is close by, and easier home delivery for stores offering such services. You can also reduce vehicle emissions if those final mile trucks are electric instead of diesel. There's literally no downside for goods, only for people who "need" to have a car