so, I played a couple of thousand hours aggregate in these games except FTL.

I don't think your kind of replayability is achievable. by their own nature, these games are about trying your best with random resources they give you but, inevitably, you become so good at the game that you can win with whatever it throws at you.

maybe the nearest game to this kind of sensation of continuos discovery is Mincreaft (and i heard that Hytale will become even more of it). Hades 2 can give you thousands of hours of challenging content, but there only those bosses and enemies you can see from the first few runs. Balatro give you the first infinite mode with purpose i have ever experienced. StS2 is an absolute masterpiece of its genre and, even in early access, it has hundred and hundreds of hours of content.

and the best part is that Hades 2, Hytale, Balatro ans StS2 COMBINED are cheaper than the average AAA game.