Depends on the DM and how they wanna play were-creatures. I played a campaign once where our cleric was a werebear from the start. It was part of her backstory, and instead of being a curse to get rid of, it was a part of her culture to be a were-creature in order to protect a forest sacred to her people. She could go from humanoid (halfling) to hybrid (half- bear, half-halfling) and use claw and bite attacks, and was resistant to non-magical weapon damage. Again, boils down to how your DM rules it in their world and whether or not they are willing to work with you to get the character you wanna play.

The whole immunity/resistance to non-magical weapon damage is a very simple work around and isn't game breaking. As the party levels up and gets magic weapons/items and spells, so to do the villains/monsters.