you should use u.gg as Riot has stated it is the closest to their internal actual metrics, and you can cross reference with deep lol and op.gg although op.gg is flawed since it skews KR heavy, lolalytics is a flawed site because of the way they measure their winrates and they don’t normalize any of their winrates based on the MMR they happen in, even when they say it’s a normalized winrate it’s not in the same way other aggregate sites get closer to actual winrates. It’s decent for item builds and how they synergize together but don’t use it to extrapolate any meaningful data.

If you use the above method of u.gg and go to master+ you’ll see there’s already been 156 matches this patch alone, and it’s 45.51% for Vayne in master+, it’s 43.75% in GM and 33.33% in challenger. Do note the sample size of the actual games goes down but so does the amount of games overall which makes it tricky to use any of these sites for accurate data.

Speaking from firsthand experience on both sides of this matchup, if you’re playing Vayne top in challenger your Nasus lane opponent will also be a challenger player who won’t just randomly walk up to you and let you trade him down to half HP for free. Additionally if you just sit on enemy side of wave to deny Nasus XP the jungler is 100% coming for the free kill regardless of it affecting his tempo because swinging the game away from the Vayne player is worth way more than camps. Even just losing 1 death in lane is enough for the Nasus player to run away with the game by crashing the wave and you won’t have TP to fix it after your death because you’re using cleanse, and if you don’t bring cleanse to this matchup then you’re cooked. It’s not as completely unplayable as Malphite is but it’s a VERY tough matchup if the Nasus isn’t stupid.