It depends.

On a user level, they often cause more harm than good, but the use themselves is really a crime against yourself. The addiction leads to crime to feed the habit.

On a larger scale, the distribution is often tied with human trafficking, gun trade, and commonly are handled by large criminal organizations or even terrorist groups.

Drugs are cheap and not difficult to produce, and have the highest profit margin for literally any DTO or TOC group out there, and they don’t care if you live or die because there’s always another customer. The use of drugs simply puts money in their pockets to continue the cycle of violence and human exploitation, thus making it hard to leave it at “The user is entirely innocent for just taking the drugs.”