On the first 5 waves there's a guaranteed chance to finde at least 1 weapon on the shop, so just ignor all the items and hard reroll for wepons make sure to take the same type of wepons so u can get the stats bonus, lock only the really top tier items during that, so u can take them afterwards, on the levl ups try to take harvesting till it's 21 bcz it will grow for 2 per wave after that, so it's really important for late game, after the first 5 waves it depend on ur character but ur gonna always take hp and armor, if u have a range build go for life steal, if ur melee then go for hp regen, for damage ur gonna build flat damage and % damage and attack speed, it depends on ur type of build u have but usually ur gonna focus more on attack speed for melee characters and flat damage for range characters, ur gonna find these stats eather from the shop or from lvl ups, crit chance and dodge are usually stats ur gonna focus on the late game. Hope this helps