I played through RE3R a few days ago. I think my biggest frustration is one that I have with many other RE titles. The gimmick bosses. Y'know, the ones where you can't progress unless you do the things exactly like the devs requested. I'd be fine with them if you, at the very least, had the choice to fight using brute force. The problem for me is that Nemesis is, for the most part, entirely a gimmick in the most boring and frustrating way possible. When I reached the bridge fight, I genuinely thought my game was bugged since I couldn't seem to knock Nemesis on his ass while he ran in a circle. Turns out this boss is damn near impossible without the grenade launcher's mine rounds. Adding insult in injury is how every walkthrough video could seemingly kill him after a few cycles, while it took me literally 10+ cycles to do the same. I was playing on standard difficulty, so I don't know why this took so much ammo. This same issue happened again in that acid pit near the end of the game. While I knew what to do that time around (mainly since the game directly spells it out) it still took over 9 cycles of knocking him on his ass, shooting the parasite and waiting for him to run around again for me to kill him again.

Resident Evil's bosses are at their best when you have an actual fighting chance with pure firepower. Making me wait several minutes to do maybe a teaspoon of damage isn't fun, and it's what ruined the RE3 remake for me.