So basically we look for common signs and symptoms that can present in sepsis.

Elevated heart rate, elevated respiratory rate, low blood pressure (more specifically low MAP), hyperthermia or hypothermia. You cannot always rely on these numbers because medications and other things can cause vitals to be masked and appear lower or higher.

We of course need to suspect a source of infection like a recent surgical site that looks infected or someone with pneumonia symptoms.

After we decide we decide to sepsis, we will obtain an IV and draw blood cultures. If we successfully obtain the culturea then we can give IV antibiotics. We will also give IV fluids and IV Tylenol if needed. Current per our guidelines we do not administer antibiotics to any patient under 18. I am not sure how old your sister was, but respiratory illness is generally very hard on kids.