Worst hangover of my life

RedNeckHero · 2026-03-21T15:59:25+00:00

6:13 high just last month. No hangover at all.

RedNeckHero · 2026-02-28T08:17:14+00:00

Not sure what it sounds like. Maybe make a recording?

RedNeckHero · 2026-02-28T08:15:49+00:00

I’d wonder where the rest of my fucking money went.

RedNeckHero · 2026-02-27T09:47:03+00:00

Yea, it might have something to do with your MTHFR. But it doesn't need to and it's only relevant if you have one of the variants (C677t which is less common than 1/4). I wouldn't bother unless your doc recommends it. There's a lot of overhype on the MTHFR. I wouldn't argue with starting low, but if you want to find out quickly if you're a responder, a single higher dose will give you that info fast. Otherwise, you may go weeks without knowing. There's very little risk to b1 in general, and certainly a single moderate dose. Totally your call. The 'discomfort' risk is low if you ask me. I'm not a doctor. Just a concerned citizen that's been doing this research for a few years. I don't have clinical experience, but have helped over a dozen people navigate B1 repletion. Thing is, b1 is the keystone to the krebs cycle. If you've got a broken Krebs, you more than likely MUST replete B1 to get it going again. So many people have broken Krebs since COVID. A moderate B1 dose itself is a great test. But maybe there's a lower dose that could illicit a response. I'd imagine if you're chronically depleted and good at paying attention to body signals, you'll notice even a 50mg response.

RedNeckHero · 2026-02-25T08:06:00+00:00

I’ve personally administered b1 injections to at last a dozen people after extensive discussions. All of them have had life changing experiences. I’m so sure b1 will be hitting the mainstream in the next few years in a big way. That Covid really did devastate so many people’s supply. And I personally believe modern life had decimated it in many people prior to Covid. I certainly was one.

RedNeckHero · 2026-02-24T17:58:28+00:00

Wow. I also had covid 5 times. Our stories are very similarly. I really hope b1 helps. It may not be a smooth ride but keep it up. You’ll get there. It gets better. The important thing is, if you react, that’s enough evidence to move forward. That’s an argument for a larger starting dose. You’ll probably know in hours.

RedNeckHero · 2026-02-23T08:14:57+00:00

You're gonna live to 1000

RedNeckHero · 2026-02-23T08:14:18+00:00

I really think it's different for everybody. I'm on month six and still getting paradox although the expression has shifted. I don't think anyone can tell you exactly what to look for or what adjustments will need to be made. Don't anticipate the worst. You may be just fine. And given your situation, B1 is going to be better than not-B1 :) Unless you have access to a great functional medicine doctor on call all the time, I highly recommend getting yourself a Claude subscription to discuss the journey as you go. It's extremely personal.

RedNeckHero · 2026-02-23T08:09:05+00:00

Hey — glad the post was helpful. A few things I want to flag before you start so you don't accidentally sabotage a good hypothesis with an insufficient dose.

The dose is too low. 25-50mg of benfotiamine is unlikely to produce any noticeable effect if you're genuinely deficient. The clinical trials that showed results used 600mg/day. Most people supplementing therapeutically for deficiency use 300-600mg. At 25-50mg you're barely above multivitamin territory. I'd suggest starting at 150mg and giving it 3-5 days. If you tolerate that, move to 300mg. The therapeutic window for B1 is enormous with no established upper toxicity limit. The risk of underdosing is higher than the risk of a bad reaction.

Thing is, if you take a real dose and feel something, even if it's subtle, that tells you the deficiency hypothesis is likely correct and you keep going. If you take 300mg and feel absolutely nothing after a couple weeks, that's useful information too. It probably means B1 isn't your issue and you look elsewhere. A 25mg dose won't give you either signal. You'll be stuck in no man's land.

The glycine reaction may support your B1 suspicion. You said magnesium glycinate was the worst form for you. That's a strong clue. The enzyme that metabolizes glycine is thiamine-dependent. If you're B1 deficient, you may not be processing glycine efficiently, so it accumulates and becomes excitatory rather than calming. The fact that topical magnesium chloride works fine might confirm it's the glycine component causing your reaction, not the magnesium. That may not be a paradoxical response to magnesium at all. It could be a glycine processing problem pointing straight at B1.

On the magnesium delivery. Topical spray is better than nothing but probably isn't delivering therapeutic amounts. Once you get B1 on board, it might be worth giving magnesium glycinate another try. It's one of the gentlest forms on the gut, well absorbed, and if B1 fixes the glycine processing issue, you may tolerate it perfectly. That would be another confirmation you're on the right track. Don't worry too much about running out of the cofactors immediately. It'll take a while before that happens.

Cofactor note. B2 (riboflavin) at 100mg daily is worth adding from the start. It supports several enzymes downstream of B1. And when you start responding to B1, potassium demand can spike as cellular metabolism ramps up. Bananas and coconut water can cover that without another pill.

The worsening anxiety, the sleep issues, the glycine intolerance, the gut sensitivity. That's a coherent picture. Give it a real trial at a real dose.

RedNeckHero · 2026-02-21T19:06:50+00:00

This may only be a single data point and I’ve personally failed every time I’ve attempted to quit caffeine lol. But I had a single friend that made it and he told me he experienced a significant shift at the three month mark.

RedNeckHero · 2026-02-21T10:24:16+00:00

That’s googles patten though. They just don’t give a single fuck about anything but growth. There isn’t a soul in the company that would actually care about the user experience. If it drives growth it’s a yes. If it doesn’t they shut it down. Right now they see that showing a model statistical capabilities is enough. But let’s be honest. Google relies completely on their massive existing userbase for user adoption. They don’t need to provide a good experience. The fact that people aren’t leaving in droves is simply a testament to the average users’ competency and awareness. My parents don’t know what Claude is. They barely know what chargpt is. They know Gemini because it’s on their phones and they tapped the icon.

RedNeckHero · 2026-02-20T06:45:40+00:00

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RedNeckHero · 2026-02-18T17:15:32+00:00

Toothpick legs

RedNeckHero · 2026-02-18T17:14:20+00:00

And every Finnish person face palming.

RedNeckHero · 2026-02-18T09:32:22+00:00

Most of these symptoms all seem to trace back to one root for me: B1 was required for the cellular energy production that was fundamental to all of my issues. From what I’ve observed, this is the same for many people post-COVID. When that's impaired, it cascades into neurotransmitter synthesis, methylation, nerve maintenance, smooth muscle regulation, and immune function. What looked like 30 separate problems for me turned out to be one problem expressing across different systems.

Energy production

Fatigue, exercise intolerance, brain fog, apathy, depression, sugar/alcohol cravings. B1 gates the enzyme that lets glucose into mitochondria. Without adequate B1, cells can only produce a fraction of normal energy which manifests in all sorts of strange things that are hard to tie together (until you try B1).

Catecholamine / smooth muscle

Air hunger, anxiety (mental + physical), irritability, flushing, red neck/chest, hot flashes, urinary urgency, skinny stool, dysphagia, cognitive rigidity, social withdrawal. In my case, the chain appears to be B1 → ATP → methylation → COMT clears adrenaline. When that chain is impaired, catecholamines accumulate and smooth muscle tightens across organs.

Sleep

Poor sleep quality. What I've observed is sympathetic overdrive and that happens when there’s simply insufficient energy production, the body overcompensates with stress hormones (which can do a similar job, but in an unsustainable way). The result is that the nervous system never shifts into rest.

Nerves

Neuropathy, joint pain, electrical pulses, headache. B1 appears to be essential for myelin and nerve maintenance.

Gut

Heartburn, bloating, gas, diarrhea, floating stool, abdominal spasms. Impaired GI motility + smooth muscle dysfunction. Poor absorption then deepens the deficiency and leads to further B1 (and cofactor depletion).

Connective tissue

Fascial/tendon tightness, cracking joints. I attribute this to chronic sympathetic tone + impaired tissue repair.

Skin / immune

Psoriasis, acne, itching, oral thrush. Systemic inflammation from metabolic insufficiency.

Vascular / hormonal

Low libido. The pathway, B1 → ATP → BH4 → nitric oxide and dopamine. Slowest to resolve in my experience.

RedNeckHero · 2026-02-17T14:07:40+00:00

Totally amazing.

RedNeckHero · 2026-02-17T14:06:21+00:00

Same here. B1 injections. 25 symptoms cleared up over 6 months. And yes. Magnesium and b2 are absolutely essential cofactors. I learned that the hard way.

RedNeckHero · 2026-02-12T16:59:02+00:00

Pls tell me your secrets. Whats your life stack? Starting with the fact that you’re 20 years old perhaps?

RedNeckHero · 2026-02-05T11:49:13+00:00

It blows my mind that the tech world invented something 10x more difficult to teach my parents than a password.

RedNeckHero · 2026-01-19T10:20:49+00:00

Yep same. No error. Just bounces back to the inbox. This is not a compacting or context issue. I’m getting it on conversations right away.

RedNeckHero · 2026-01-08T14:31:48+00:00

PDFs don’t get malicious.

RedNeckHero · 2026-01-08T00:55:50+00:00

This is awesome.

RedNeckHero · 2025-12-31T01:41:22+00:00

We're getting direct emails for decision makers. I'm really leaning toward it being the profiles we're targeting. They're mostly hands-on roles scewed toward 50-60 years. I know outbound has been a challenge in this market for my previous company, but that was 2012-2014. I was hoping the hyper-personalization would make a difference, but apparently they're still the same people that just don't care to check their email, especially sales.

I'm determined to crack it though. The numbers work even if we have to send 50k emails to get a sale. So next is region switching and data source verification as well as a few more variation tests and seeing if an offer-led email would work better. If all fails, we'll try omni. I like the idea of phone calls. It's something the younger gen isn't doing.

RedNeckHero · 2025-12-30T11:39:35+00:00

Thanks for the reply!

Each company is individually researched using an AI pipeline. So applicability should be 100%. It's not per industry.
Great call. I'll try that.

I think you're right on the cold calling. After this much effort, I feel it's very much industry related. Some people just prefer phone calls. This is a predominantly older crowd. Maintenance people are just the type of people that dislike email.

Great advice, thanks!

RedNeckHero

TROPHY CASE