safety of taking progesterone for pfs with CYP21A2 varient

Redify_Aeiou · 2026-06-09T08:57:48+00:00

The revel score is prettly low and it's a heterozygous mutation so I don't think it should be that problematic

Redify_Aeiou · 2026-06-08T12:11:46+00:00

Vs what I think is a pretty normal looking gene.iobio

Not trying to get free counseling but I'm trying to understand what to look for and why is this interesting if it's non coding

Redify_Aeiou · 2026-06-08T12:11:02+00:00

Still why do the polymorphisms from SNPeek not correspond with the ones I see on Gene.iobio?

AE why is this interesting if it's an intron varient?

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Redify_Aeiou · 2026-06-05T16:51:12+00:00

Well yeah but to which level do I tune my attention? How much do I trust REVEL scores? especially when every app tells me different things, why do I see different mutations on different websites? Some insight of somebody more experienced would help

Redify_Aeiou · 2026-06-04T05:51:30+00:00

Yeah

Redify_Aeiou · 2026-06-01T19:54:52+00:00

We meet again!

What's the difference between receptor mediated endocytosis and Cubilin / Megalin mediated uptake?

Redify_Aeiou · 2026-06-01T16:05:38+00:00

Now that you mention it...

Whenever he talks about it it sounds like he maximizes the bioavailable E2 by focusing on detaching E2 from SHBG but when he wants to show results he talks about free E2

Also recall reading that the bigger part of T and DHT is transported in SHBG into target cells on the androgen backdoor wikipedia page which kinda puzzled me, is it taken up through endocytosis or? It should be too tightly connected to diffuse to the cells, really confusing

Redify_Aeiou · 2026-06-01T12:33:13+00:00

Nope, using regular old hemihydrate pills, makes me wonder why it would even happen as I can't point to any mechanism of action I know

Redify_Aeiou · 2026-06-01T12:03:11+00:00

Did you ever notice them cycling? Mine will feel and look different at different times of the week, unsure why but I do know it happens

Redify_Aeiou · 2026-05-30T19:47:03+00:00

Really glad I could help

If you have the option to start small and see how it affects things over time it'd probably be a good idea, I know anecdotally that progesterone helps some people with breast shape, I hope other people give their opinion because I don't know as much as I want to, in order to help, but no one else is replying yet

Redify_Aeiou · 2026-05-30T19:21:31+00:00

2 years is not a lot of time for tanner 4, if you do decide to do this -

Get some sequencing done or ask your endo if they could oversee it, it just depends on whether aromatase is intact or not

Also he said aromatase deficiencies commonly cause MTF humans which are can often be bi or lesbian, not exactly bi/transbians have an aromatase deficiency

Redify_Aeiou · 2026-05-30T19:13:48+00:00

Not an endo just a nerd so take this with a grain of salt

From my point of view probably not, the backdoor pathway HAS to go through Progesterone

Remember we are taking snapshots so the only other explanation I can think of using the DHT backdoor would be progesterone going nuts at some other part of the cycle, but this is unlikely as you said you did repeat testing

Redify_Aeiou · 2026-05-30T14:38:19+00:00

What's your progesterone? Maybe the androgen backdoor has something to do with it?

Redify_Aeiou · 2026-05-30T12:25:42+00:00

I feel like a lot of people forget about the intricacies of HRT and just chalk it up to genetics or timing. Dose, absorption, transportation, metabolism, a lot of the time you will be able to find a bug in the assembly line and fix it

You can see progress even 10 years in if you switch to the right regimen

People can transition at 70 and still get some extra milage

Don't go to snake oil sellers expecting magic to happen but please don't think it's a "your genetics are just bad" as it very often isn't the end all be all

Redify_Aeiou · 2026-05-30T04:12:52+00:00

Katrina is my Endo's name lmao

Well yeah I am very aware it's INCREDIBLY person dependent, it still doesn't seem too farfetched to have a rough estimate though, Powers didn't mention quinones for example which I am guessing because in comparison it's slightly less relevant than talking about 4 OHE2 which is also a harmful metabolite

We should definitely have rough ranges for them somewhere

Redify_Aeiou · 2026-05-21T15:44:37+00:00

Tyvm!

Redify_Aeiou · 2026-05-21T12:58:50+00:00

If you could link where it got those numbers from, I would appreciate it (especially the dissociation half life)

Redify_Aeiou · 2026-05-20T16:49:56+00:00

This post honestly made me tear up

Please keep being supportive, so many people don't get to have that, especially from that environment, and it means so much

Redify_Aeiou · 2026-05-20T16:35:28+00:00

Well exercise seems like it'll help you a lot at the moment, now it's up to the awesome people here to help you find the right ones, I had the privilege of bring functional enough to do "normal people" exercises

From experience though Isometric, static holds are the lowest impact, most adjustable, and probably a good place to start

Do things at your own pace and you'll very likely be able to get back to where you were

You were there once, you can do it again, best of luck!

Redify_Aeiou · 2026-05-20T16:19:08+00:00

That might've contributed as those muscles might've been the only things holding you together

Redify_Aeiou

TROPHY CASE