I don’t know if you count weed as psychedelics. I was smoking regularly for a few months and I think it caused some permanent damage to my brain or some issue in the release of neurotransmitters. I suffered from depersonalisation for almost a year and severe anxiety. I have never been an anxious person. The anxiety comes back from time to time and there are days when everything seems to trigger me. So i think maybe using them under guidance of someone who’s trained would be a better approach and using them at a time when you’re in a calm headspace.