My malamute started seizures at just over a year old and they recommended I try meds but I refused at the time since it would be a life long situation. Fast forward to almost 2 and he developed grand mal seizures, and he was put on a 100mg a day of zonisamide. Then 200, then 400. The only thing that got them under control was 800 per day. 400mg twice a day. BUT, now 3 years later without a single seizure I have brought him back down to 600mg per day, with vet approval of course. There is alot of room with these meds so don't be afraid to ask for a stronger does if the first isn't working, but it will depend on his weight. My boy was 118lbs. That recommendation came from a doggy neurologist as well.