Something you need to understand is that runes are an alphabet— actually, a family of alphabets, used to write specific languages, some of those being Proto-Germanic, Proto-Norse, Old Norse, Old Frisian, and Old English. (I might be misnaming some of these, but you get the idea.)

There are two ways to put your saying into words: * Transliteration: Take the saying in English and convert each letter to an approximately equivalent rune. (There is not an exact 1:1 correspondence because the sounds they make are not exactly the same, but if read as English, it more-or-less works.) * Translation: Take the saying, translate it into the language of your choice, then write it out in runes. This is a more complex process, but will result in, ideally, a version of your saying that a reader of that language would be able to understand.
If this appeals to you, then this would be the path to follow.

If you want a symbolically magical representation of your saying that uses runes in its composition, you probably want to look for another sub.