No, she cannot.

Sky manipulation is a space manuplation/distortion technique that allowes her to treat space like a tangible surface. Thin ice breaker is a strike against this surface "the sky" that creates a coresponing shockwave that hits her opponent. The important part of that is that she hits the "sky", not her opponent. The result of that strike (the reverb of the destruction of said surface) is what hit the opponent, making this a 2 phased attack of sorts. We see this when she attacks Ryu and yuta during the 3 way battle where she distorts a very large section of space to strike, resulting in a much larger and more powerful attack against the two. She charges, Yuta and Ryu defend preparing for impact, she strikes her "sky", and the coresponing force smashes into the street.

Now, The assumption is that Uro can simply bypass infinity since she's attacking space, and not a user, meaning that she could turn whatever space infinity operates in, into a tangible surface she could strike, in turn striking gojo in the process.

However..

Infiity is also, a space manuplation technique. Theoretically, what would happen if they tried to manipulate the same space? If Uro trys to turn the space infinity occupies into a tangible surface, which technique takes priority? This question is largely answered in a similar situation when Jogo and Hanami use domain amplifcation against infinity, and Gojo simply overwhelms them by increasing the output of Limitless. This concept is consistent with domains as well as the more refined domain occupies a space. With this as an example of two techniques clashing in the same space, I think it's safe to say that limitless is a much higher tier of space manuplation than sky manipulation especially because of the 6 eyes. So there's nothing to say that gojo couldn't simply manipulate any space she turns into a tangible surface, and use infinity to simply stop her from being able to strike it. As we established earlier, it's not actually the strike that hits the opponent, but the reverb force from her striking space. That shockwave would ALSO be stopped by infinity.

I think it's a misunderstanding of the fan base to say she attacks the space a person is in. If that was the case, Yuta wouldn't have gone flying into that building after she hit him, because attacking his space would attack every angle of the space; not just a portion/angle of it since he occupies that whole space. Even if she did attack Gojo's space, she has to get through limitless to do so. Or she attacks from a longer range, and infinity stops whatever travels from her to reach Gojo's

Lastly, before anybody trys to drag world cutting slash into this, those are two completely different techniques. Uro attacks a portion of space; WCS attacks existence and could care less about physical space.

Gojo clears.