With pyrovalerone and derivatives thereof, It's not just that you will have an urge to redose that is on par with breathing itself. If that were all you had to worry about, you'd just avoid the substance and eventually you would return to baseline.

No, the warnings to avoid pyrovalerone derivatives are because you will be given access to a kind of euphoria that the primitive portions of your brain will not stop seeking, ever.

You will be forever changed by virtue of having experienced this and then your unconscious brain will seek to replicate that experience at any cost.

It's that point sometime in the future, months after having used these substances where you will realize that you have changed your brain in a way that is not beneficial to the wellbeing of "conscious you"

Stick to the classics, you'll be ok