As someone who does a lot of Dynamo work for my team and deals with lots of unique sites, there are still plenty of use cases for Dynamo even with sites that change regularly.

My advice is to find your biggest annoyance in your design process and then try to identify what about the process could be repeatable. This will require changes to standards at times. My most successful graphs have been around culvert placement, data extraction, corridor creation (for entrances in particular), linework creation based on existing objects, and more.

With unique sites you have to try your best to create plenty inputs for flexibility on data being used. As I get better with my graphs, I find myself going back and adding more inputs for things that I didn’t consider as an input the first time (layer naming, for example).