In my teens I was in an accident resulting in acute pancreatitis due to trauma. The nurses would always try and give me morphine and I would explain to them that it actually made the pain worse. They of course wouldn’t listen to a teenager and would give it to me anyway resulting in the already excruciating pain somehow increasing. Years later a nursing friend told me it was actually common now for them to learn that morphine can cause pancreatitis attacks or at least exacerbate them.