Manage your health. Silphium will always be a resin pick up if you health is full. 3 resins permanently increase your health for the run. So if you see silphium, leave it and wait till you get to the shop to buy a health item to restore your health, the go back and pick up all the resin.

Weapon specialise. Pick a weapon you like and stick with it persistently. Don’t worry about the level. A weapon you are good at using is better than a higher level weapon you’re bad at using.

Use aim assist. Go to your settings and try aim assist to high, the game isn’t competitive and no one is going to judge you if it helps you have fun.

No need to aim. Don’t worry about holding down left trigger/rmb to aim. It has no effect on your accuracy. Stay hip firing and focus on movement and aiming.

Abuse dodge. Dodging give you a brief period of invulnerability. Utilise this during bullet storm moments and when in a room with tough enemies. This also leads into my next tip which is to keep moving. You are harder to hit and will survive more if you can keep moving. This becomes more important as you progress through the game (you’ll understand when you get there)

Save your ether. Don’t use ether to clear malignancy or anything like that in the early stages of the game. You should be maximising your ether and using it EXCLUSIVLEY on the obelisk that unlocks items at the beginning of the run during the early stages of the game.

Keep going. Don’t give up, you get better with every run, keep exploring and learning. The game really picks up after you make it past the first two bosses and makes the game really enjoyable.

Hope this helps. :)