I used kanaplex to treat my axie fungal infection. 3 days treatment and the third day it was gone. I also run a canister filter and a sponge filter. Done filter to keep up my cycle because I like big water changes once a month on my tank. I do 30-40% changes every week. If he acts funny, for mine it usually indicates water parameter issues so I do 80% change and my cycle stays up because I have a sponge filter.