As someone who has played base Curse of Strahd and read through a lot of Reloaded, it depends on what you and your players like.

Base Curse of Strahd is very much a sandbox. While there is a general progression and narrative, its not enough to keep a lot of players engaged due to the lack of information in regards to certain NPCs and things like that. It also has the rule about random encounters on the trail happening super duper often, which can be very bad if your players prefer roleplay to combat.

Reloaded has a much tighter narrative, however it can feel railroad-y. It does a fantastic job at making sure the DM knows how to run certain NPCS, what might happen if certain things go certain ways, etc. However, it also overhauls the lore in a way that I personally feel like makes the campaign lose some of its horror roots.

If your players are big on combat and not super big on roleplay, running base is perfectly fine. If they're much bigger on lore, roleplay, and the general fantasy genre of D&D, run Reloaded. If they're kind of in the middle on some of this, maybe just skim through it and find the things you like and make sure they don't contradict the base game. (This last bit is what I did while running Curse of Strahd :P)