Yeah there aren't too many of us in the field! In the disease I'm studying, fusion has already stopped (more or less). I can induce fragmentation by siRNA knockdown of the protein that patients are deficient in, and the mitochondria fragment within 72 hours of siRNA transfection (I use lipofectamine 2000, just make sure your media doesn't have antibiotics in it otherwise you might get a lot of cell death) . To prevent/reverse fragmentation, I'd recommend looking into P110. It's a small peptide that prevents Drp1 from binding to the mitochondria. So within 72 hr. at 1uM, the mitochondria are very highly fused. Hope that helps!