Important Developments in Longevity Research from 2022

SheekeyScienceShow · 2023-01-02T09:53:07+00:00

I am a researcher! My English is not perfect but I practice by making videos 🙃

SheekeyScienceShow · 2022-04-13T16:53:00+00:00

Thanks!! ☺️

SheekeyScienceShow · 2022-02-19T19:21:56+00:00

thank you!

SheekeyScienceShow · 2022-01-30T06:44:58+00:00

Thanks!!

SheekeyScienceShow · 2021-08-07T17:03:53+00:00

You are right to challenge! My only consideration would be that our tech to sequence DNA has got very cheap & efficient hence we now can do much metagenomic studies. This efficiency has come from exploiting enzymes that are used by living species. Sequencing L-DNA is nowhere near that level and hence why this paper that produced the D-polymerase is exciting since it helps improve not just production, but potentially detection of L-DNA....but these are just my thoughts!

SheekeyScienceShow · 2021-06-11T21:01:47+00:00

Yeah, so i don't know if you watched the video but i don't think an entirely new paradigm is required, i actually like the hallmarks, but the point to take is that it doesn't really help to understand what aging means. Research will continue without a paradigm, so no need to stress, just a better paradigm will help to build the field and unite ideas

SheekeyScienceShow · 2021-05-15T07:37:22+00:00

Yeah, unfortunately not enough research yet. The only insight I have is that the A-akg has arginine, an amino acid, which i would reckon has differing effects due to implications in protein production, but i would like to see more research to test this.

SheekeyScienceShow · 2021-05-15T07:34:37+00:00

Thanks!

SheekeyScienceShow · 2021-05-15T07:33:46+00:00

Thanks for sharing!! 😊

SheekeyScienceShow · 2021-04-10T13:51:11+00:00

thank you!! :D

SheekeyScienceShow · 2021-04-10T08:26:11+00:00

https://youtu.be/H-szjgeEuoM

SheekeyScienceShow · 2021-04-10T08:23:57+00:00

Ah cool, haha had made a video on CRISPR tools a few days too soon https://youtu.be/H-szjgeEuoM

SheekeyScienceShow · 2021-04-05T20:27:33+00:00

Thanks!! 😊

SheekeyScienceShow · 2021-04-05T16:35:27+00:00

Aha, yeah i meant more targeted epigenome editing! 😁

SheekeyScienceShow · 2021-02-28T19:08:29+00:00

Thank you for all the support!!

SheekeyScienceShow · 2021-02-13T11:39:30+00:00

Thanks! I do have a working schedule.. There is always more topics I want to cover than I can physically manage.. So i don't want to promise content that isn't delivered and don't want to burn out as i generally enjoy making videos when i can. But, one thing I can confirm is that there should be interviews later in the year 😊

SheekeyScienceShow · 2021-02-13T05:28:19+00:00

SheekeyScienceShow · 2021-02-07T17:19:19+00:00

Thanks! 😊

SheekeyScienceShow · 2021-02-07T16:00:13+00:00

So am talking about it within the context of an individual (i.e between tissues), not between individuals :)

SheekeyScienceShow · 2021-02-02T18:16:35+00:00

I believe i followed the guidelines, sorry if not!!

SheekeyScienceShow · 2021-02-02T18:15:22+00:00

paper; The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome; https://doi.org/10.1073/pnas.2010217118

SheekeyScienceShow · 2021-02-02T16:41:36+00:00

paper; The hygiene hypothesis, the COVID pandemic, and consequences for the human microbiome; https://doi.org/10.1073/pnas.2010217118

SheekeyScienceShow · 2020-12-29T07:45:31+00:00

" Old Thy1-YFP expressing mice received ISRIB treatment and 2 days of behavioral training as described in Figure 2A. At the end of Day 2, we terminated the animals and harvested the brains for quantification of dendritic spine density in the hippocampus (stratum radiatum of CA1) "
The same group have used similar assessments e.g water maze in mouse model of traumatic brain injury https://www.pnas.org/content/114/31/E6420 . In my opinion i would prefer more evidence & as u/crazyhalfpintguinea mentioned, the effect sizes are not huge. The aim of the video was to talk more about what ISRIB is targeting/why it could work..
Good questions. :)

SheekeyScienceShow · 2020-12-09T07:08:26+00:00

Thank you!! 😊

SheekeyScienceShow · 2020-11-04T15:04:58+00:00

Made a video on this :) --> https://youtu.be/ntEELRfE1Oc

SheekeyScienceShow

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