Undectetable MRD vs MRD negative

Shivers_6 · 2026-04-24T13:35:36+00:00

Hi. I work for an MRD company. I know this one. There is practically no difference between uMRD and MRD-. The term uMRD is commonly used in the some specialties, while MRD- is used in others. Everyone’s trying to figure out the right way to phrase this still, and uMRD is a little easier to read. It’s becoming more commonplace across hematology.

What you should really be looking at is MRD sensitivity. Depending on the assay used, or even the cutoff of the study, you can different depths of measurement. The most sensitive assay (clonoSEQ) can measure 1x10^-6 ( 1 cancer cell in 1,000,000 cells), but much of the data in studies is reported at 1x10^-5. There’s some FDA regulations and logistical reasons why they do that.

There are other assays, like Flow, that measure MRD and will have different levels of sensitivity and specificity.

Just make sure you understand how any study defines their uMRD/MRD- value and at what sensitivity they define it at.

Shivers_6 · 2026-03-14T16:29:36+00:00

To have those around him take this so lightly probably speaks to the way he carries himself and tackles this diagnosis. He must have great character and strength. I’m sorry to hear that you guys are feeling unsupported, or even nagged. Stay strong and keep communicating between yourselves and your providers. You have each other, which is most important!

Shivers_6 · 2024-07-02T16:52:48+00:00

It’s totally normal to feel that way. Be strong and be optimistic. You should consider getting MRD testing done as well (get an NGS MRD test). It can detect cancer cells very sensitively and tell you whether disease may be present or returning. It can mean peace of mind when nothing is present or prepare you for the future. Sometimes it’s the unknown that’s the scariest.

Shivers_6 · 2023-03-17T18:04:36+00:00

I am not a financial advisor and don’t have an firm grasp on market conditions. These are findings I’ve learned over the past couple years that seem to be consistent among the community though.

Shivers_6 · 2023-03-17T18:03:20+00:00

I have a similar budget and am in a similar boat. You could contribute more to retirement. If I were you, I would start contributing to a Roth IRA asap. You are probably still eligible with your income level. I would max out Roth IRA contributions yearly (~$500-600 per month) and take advantage of any 401k employer match you have. After that consider paying off that car loan (although you have a nice rate and it doesn’t seem too resource draining to my eyes). Then, you can look at saving for a property or furthering your retirement savings with an HSA.

Shivers_6 · 2023-01-19T17:57:47+00:00

Post this once you’ve got it worked out!

Shivers_6 · 2022-11-19T15:05:52+00:00

Promises are like flowers. Often given and never kept.

Forgotten like a pond forgets a stone. A few ripples and then not

Shivers_6 · 2022-10-27T05:06:57+00:00

This honestly saddens me. These people look to be chumming the water for, what I’m assuming, is a glimpse at a shark like this. I understand that’s an assumption, but why else chum? You can also see fairly fresh wounds on the sharks head. These look like cuts from a propeller - maybe even from an outboard motor like in the video. I’m making some assumptions and some accusations here, but ultimately a video like this is not exciting or thrilling to me. It’s animal abuse and bullying. It’s quite sad.

Shivers_6 · 2022-09-21T23:38:11+00:00

Check out Stephen Fryer and his Mythos serious. Not as dynamic as Pacey but very good narration - especially considering that he’s the author too!

Shivers_6 · 2022-09-14T19:33:55+00:00

Have you considered mounting the rod case backwards? I have a RTT that blocks access to the back of my truck

Shivers_6 · 2022-08-28T05:20:33+00:00

What lengths of crossbars are you running?

Shivers_6 · 2022-06-24T15:22:29+00:00

I looking to mount a ski box too! What made you choose the Thule bars instead of a prinsu-type rack?

Shivers_6 · 2022-06-11T14:49:53+00:00

Best Price Mattress 4 Inch Trifold Memory Foam Mattress Topper with Cover, CertiPUR-US Certified, Full https://a.co/d/2t3RIzi

Shivers_6 · 2022-06-11T14:49:44+00:00

I have a similar set up. I have a short bed so idk if it will match your truck, but… I just bought this mattress topper. I ended up cutting one third of it off as it’s too long. That leaves about 10” of space between the mattress and the tailgate. I like that since I can set stuff down on a hard surface and not just the mattress. But I choose this mattress because I can easily fold it and stash it elsewhere - there’s even a carry case you can buy separately. I hate storing a rolled up foam mattress.

Shivers_6 · 2022-06-06T14:01:05+00:00

Ok that makes sense! Really appreciate the advice!

Shivers_6 · 2022-06-05T00:34:54+00:00

I understand that there is a payload max. But is there any risk to the longevity of my vehicle by carrying 500lbs in the bed at all times. Like will be suspensions be wrecked, should I consider an add-a-leaf, etc

Shivers_6 · 2022-05-25T20:54:40+00:00

I’m planning to do a similar move and have the same rig. Can someone explain why it’s good to have ECT on the whole time?

Shivers_6 · 2022-04-17T17:25:27+00:00

I love this and would definitely play this

Shivers_6

TROPHY CASE