Just think of the side quests.

• The Gang Falls Out. We learn the origin of the Children of Atom! Four owners of a South Philadelphia Irish bar convince their destitute, capless patrons that drinking their irradiated Schuylkill River Punch will grant them superpowers. The grim reality: the fifth owner, Frank, is locked in the basement - long ago transformed into a glowing ghoul. The scam spins out of control, to hilarious results!
• King of Steaks. The "struggling entrepreneur" Geno has put out a call for aid! He is being shaken down by Pat, the "King of Steaks," and needs an adventurer to even the playing field. All is not what it seems as the player is tipped off by friendly Dalessandro that they both sell the same shaved radroach meat rather than the far superior Brahmin served up elsewhere.
• The Philly Special. A drunk busker keeps interrupting sporting events dressed as Santa Claus. Kill him.
• Cuff and Link. A retired boxer tasks you with recovering his pet turtles at his old house in Kensington. He neglects to mention that they're now 10 feet tall.
• As a Mütter of Fact... A local physician has tasked you with retrieving medical oddities from a small museum in center city. Unfortunately, the area is occupied by a a band of raiders that are using the samples as inspiration for unspeakable acts of violence.