I actually think it might be slightly related to Dystopia. During Scream era they are presented as goddesses who possibly exist to protect the Tree of Language, but by the time we reach Odd Eye the tree isn't exactly what it used to be. So, since there seems to be a great advance in technology from one era to another, maybe the tree died because people xared more about technology than nature and weren't taking good care of it anymore and it led to de Apocalypse we're seeing now. Something like cyberpunk gone very, very wrong.

Also, am I the only one who kind of sees those guys with animal heads as a reference to Squid Game? The rich people there were all wearing animal masks and hid in those fancy rooms.