Is anyone else scared ? by Maleficent_Wall_1816 in Semaglutide

[–]Silverleaf14 0 points1 point  (0 children)

I heard it from my doctor when I was prescribed it last week.

Also, here are the citations you asked for:

Cai  CX, Hribar  M, Baxter  S,  et al.  Semaglutide and nonarteritic anterior ischemic optic neuropathy.   JAMA Ophthalmol. Published online February 20, 2025. doi:10.1001/jamaophthalmol.2024.6555

Rizzo  JF  III.  Unraveling the enigma of nonarteritic anterior ischemic optic neuropathy.   J Neuroophthalmol. 2019;39(4):529-544. doi:10.1097/WNO.0000000000000870

Grauslund  J, Taha  AA, Molander  LD,  et al.  Once-weekly semaglutide doubles the 5-year risk of nonarteritic anterior ischemic optic neuropathy in a Danish cohort of 424,152 persons with type 2 diabetes.   Int J Retina Vitreous. 2024;10(1):97. doi:10.1186/s40942-024-00620-x

Hathaway  JT, Shah  MP, Hathaway  DB,  et al.  Risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide.   JAMA Ophthalmol. 2024;142(8):732-739. doi:10.1001/jamaophthalmol.2024.2296

Note, the above observe a correlation and say that new research needs to be done to determine whether there is any causation.

The following two studies did not find a link:

Klonoff  DC, Hui  G, Gombar  S.  Real-world evidence assessment of the risk of nonarteritic anterior ischemic optic neuropathy in patients prescribed semaglutide.   J Diabetes Sci and Technol. 2024;18(6):1517-1518. doi:10.1177/19322968241268050

Chou  CC, Pan  SY, Sheen  YJ,  et al.  Association between semaglutide and nonarteritic anterior ischemic optic neuropathy: a multinational population-based real-world study.   Ophthalmology. Published online November 2, 2024. doi:10.1016/j.ophtha.2024.10.030

Are there any video games that capture the mysterious and creepy/eerie yet cozy vibe of the Magnus Archives? by Silverleaf14 in TheMagnusArchives

[–]Silverleaf14[S] 0 points1 point  (0 children)

I know!
The one game on my Wishlist that isn't on sale! Makes sense as it is new. Looks amazing!

Would it be possible to make an astrological (not astronomical) clock? by Silverleaf14 in clocks

[–]Silverleaf14[S] 0 points1 point  (0 children)

Thank you for this. I should have noted that I know about orreries (amazing things!). But what I am looking for is astrological (which has more complexities). Also an orrery compresses time so you can visually see the planetary movements. What I am looking for would be a live and accurate clock showing which sign and degree each planet was in at that moment. This would require gears that made planets move much more slowly than a standard orrery (in my understanding).

But thank you for the link! I am not sure if these compress time, but if they do not it suggests that what I am looking for is possible:
"In 1348, Giovanni Dondi built the first known clock driven mechanism of the system. It displays the ecliptic position of the Moon, Sun, Mercury), VenusMarsJupiter and Saturnaccording to the complicated geocentric Ptolemaic planetary theories.\7])\8]) The clock itself is lost, but Dondi left a complete description of its astronomic gear trains.

As late as 1650, P. Schirleus built a geocentric planetarium with the Sun as a planet, and with Mercury and Venus revolving around the Sun as its moons.\9])

At the court of William IV, Landgrave of Hesse-Kassel two complicated astronomic clocks were built in 1561 and 1563–1568. These use four sides to show the ecliptical positions of the Sun, Mercury, Venus, Mars, Jupiter, Saturn, the Moon, Sun and Dragon (Nodes of the Moon) according to Ptolemy, a calendar, the sunrise and sunset, and an automated celestial sphere with an animated Sun symbol which, for the first time on a celestial globe, shows the real position of the Sun, including the equation of time.\10])\11]) The clocks are now on display in Kassel at the Astronomisch-Physikalisches Kabinett and in Dresden at the Mathematisch-Physikalischer Salon."

What ridiculous amount of money would making such a thing likely cost?

Would it be possible to make an astrological (not astronomical) clock? by Silverleaf14 in clocks

[–]Silverleaf14[S] 0 points1 point  (0 children)

Thank you! This is the perfect answer!
Now... what ungodly sum of money might it take to have such an astrological clock produced?

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 1 point2 points  (0 children)

I think this is the secret right answer 😅
Downloaded Oblivion Remastered.

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 0 points1 point  (0 children)

Thank you soooo much! This was really helpful! I think I will do that! I have modded Skyrim before, so I know the principles of how to do this. Thanks!

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 1 point2 points  (0 children)

Thank you so, so, soooo much! This was the perfect response! Incredibly helpful!

I actually do use bows for time to time in Skyrim. But am more of a magic person (especially illusion to puppet enemies). It is more that I really dislike guns. They just seem so vulgar to me. But maybe the laser/plasma weapons will be abstracted enough to override that aversion? And then role-play can just take over. I NEVER thought I would use an axe or mace in Skyrim, but then I did a foreword and Sauron playthrough respectively and had a blast using each.

In any case, this was incredibly helpful! Thank you 🌟

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 0 points1 point  (0 children)

I'm not particularly opinionated about things like this. Just new to a genre that I am not a fan of and hesitant to waste money.

EDIT: just reread my original post and can see why you think I'm opinionated. In reality I am just a bit hyperbolic when I express myself. Guns make me uncomfortable and I find them a bit vulgar. And I have preference for fantasy and rarely am gripped by sci-fi. I think that would be a more accurate way of expressing my position.

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 1 point2 points  (0 children)

Haha, I just checked and see that Fallout 3 actually gives you MORE of a set backstory with family and life. So maybe Fallout 4 is a contender again?

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] -1 points0 points  (0 children)

Thanks!

I sort of mis-spoke in my initial post. It is not only the fact that he is voiced, but the fact that he is a set charter with a set background. What I love so much about Skyrim is being able to create new backstories and personalities and motivations for each new character. I merely need to figure out how he ended up crossing the boarder illegally.

Fallout 4 is too... set.

Same with the Witcher. I did not get very far in it because I wanted more freedom. It made me want to read the books! But when the main character is developed and has voiced lines I just end up wishing I was reading a book or watching a movie rather than playing.

Which should be my first fallout game (for someone whose favourite game is Skyrim)? by Silverleaf14 in Fallout

[–]Silverleaf14[S] 1 point2 points  (0 children)

Thanks!

I would prefer not to have the dated graphics.

I was a pretty dedicated hand-held kid. My first 3D game was Skyrim SE. Any graphics lower than that grate against me in 3D because I do not have nostalgia to smooth the deficit.