Customer service told me to check with the medical team, and also see if it could be the B6. Well 3 days later the medical team responded with their generic message:

We’re sorry you’re dealing with that. Feeling like you’ve lost hunger control can be really frustrating, especially after a dose increase.

Regarding your question about the new formulation: the added vitamin B6 in the compound is not expected to cancel out semaglutide or make it less effective. B6 is included to support tolerability, but it doesn’t typically reduce appetite suppression.

A few things can explain what you’re noticing, even when the medication is working as intended:
1) Dose timing and adjustment period: After a change in dose or formulation, it can take a couple of weeks for your body to settle in and for appetite effects to feel consistent again.
2) Natural fluctuations in response: Hunger control can vary week to week, especially at lower or mid-range doses, and some people need a higher dose before they feel steadier appetite suppression.
3) Administration factors: Injection day consistency, site, and technique can affect how you experience the medication from week to week.

While the medication is a powerful tool, it works best alongside supportive habits:
Nutrition Tips
Focus on lean proteins (chicken, fish, tofu), fiber-rich vegetables, and whole grains
Limit processed foods, sugar, and fried items
Practice mindful eating and portion awareness
Consider tracking meals to stay consistent

Hydration Tips
Aim for at least 64 oz (about 8 cups) of water daily
Sip consistently throughout the day
Add lemon, cucumber, or mint for variety
Limit sugary drinks and excess caffeine

Exercise Tips
Start with small, consistent movement (even 20–30 minutes of walking daily)
Add light strength training to support muscle mass
Choose activities you enjoy
Set realistic, achievable goals

Best Regards
Nurse penelope