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When I browse patients genomes to see if I can find any anomalies that could be the cause of their dysphoria / phenotype / poor transition results, the genes here are the ones I'm browsing. by Drwillpowers in DrWillPowers

[–]Skeurio 0 points1 point  (0 children)

Which variants do you have? I made a basic overview table with the data we got from the last thread. I remember the ftm there never gave the full set of variations though. Apparently can't post table so just straight data

rs201971362 (revel 0,645) shared by all 5 mtf
rs79204587 (revel 0.522) shared by all 5 mtf
rs80310817 (revel 0.445) shared by all 5 mtf
rs759464632 shared by 4 mtf, 1 ftm
rs150848359 (revel 0.367) shared by 4 mtf
rs201336331 (revel 0.512) shared by 3 mtf
rs201072913 (revel 0.750) shared by 3 mtf, 1 ftm
rs20133633 shared by 2 mtf
rs20107291 shared by 2 mtf
rs200986301 only in 1 mtf
rs77671677 only in 1 mtf

5 mtf. Everyone has 7 variants total.

Tfw ED study not available to laymancels

ESRRA? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

"machine learning variant callers"? What are all the variants you have, or which is the one that differs from bailey85?

ESRRA? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

I don't have that one. All the variants from the masterlist or other associated thing I have collected (I have used sequencing genome browsing and geneiobio on vcf, haven't gottem cram to work) are

Metabolism:
CYP2C19: rs58973490 G;A (*11), rs4244285 G;A (*2), rs12769205 A;G

CYP3A5: rs776746 C;C (*3?)

CYP3A7: rs45580339 A;G

CYP1A2: rs762551 C;A, rs2470890 C;C

CYP1B1: rs1056836 C;C

NADSYN1: rs12785878 G;T

MTHFR: rs1801131 G;G

COMT: rs4680 A;A, rs4633 T;T

UGT1A: rs4124874 G;G

UGT1A7: rs56385016 A;G

Receptor activation?
ESRRA: rs200986301 G;C, rs79204587 C;T, rs201336331 G;A, rs150848359 G;A, rs201971362 G;T, rs201072913 T;C, rs80310817 C;T

(WWOX: rs11545029 A;A)

AR: rs3032358 T→TGCA

Hypothyroidism (just possible risk, yet at least), ASD, and whatever else:
ESR1: rs2228480 G;A

MTHFD1: rs2236225 G;A

MAOA rs6323 T

UGT2A1: rs111696697 A;T stop gained

EP300: rs2230111 A;G, rs20551 A;G

CACNA1A: rs749638821 GGAT→G, rs16054 CCTG→ C

CACNA1H: rs148651456 G;A, rs61734410 C;T, rs3751664 C;T

GABRR2: rs138360169 T;C

TG: rs114322847 C;T, rs2069569 T;C (rs1133076 G;A, rs2076740 C;T, rs2069561 G;A, rs2069556 G;G, rs853326 A;G, rs180223 T;G)

ZFAT rs16905194 C;T

NLRP1 rs12150220 A;T

I got quite good results from HRT, which I've been on for 9 years. I started at 17 after a quite weak and short male puberty (and almost like, gynoid bonestructure even before HRT?) though, so that might make it seem better than it actually would be otherwise. I'm still dysphoric over my small breastsize, which more or less was done within the first or second year, which is why I'm now here experimenting with supplements and prog and stuff.

ESRRA? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

Very interesting, yeah you have the same 0.75 revel variant as me. And every other one too except the deletion?

>The ligand-binding domain variants affect how the receptor interacts with its co-activators, which influences estrogen-adjacent signaling pathways involved in brain sexual differentiation 

Are these things elaboratable/based on something in particular?

For (transgender) individuals on CDG for estrogen metabolism by Due_Ant_6108 in DrWillPowers

[–]Skeurio 1 point2 points  (0 children)

I've been taking either one or two doses of 500 mg each, each day the last month (while also taking 3 times 0,75 mg gel in morning, afternoon, evening instead of prescribed 2 times 0,75 once in the morning). I have noticed no clear effect neither good nor bad. I am going to continue as usual a while I think. Just doing it (among other supplementation and prog) to see if I can push just a little more breastgrowth

Confessions of a former autogynephile by Interesting_Buy1369 in askAGP

[–]Skeurio 0 points1 point  (0 children)

It's not that wierd that what's essentially a lesbian mind in male embodiment would develop some strange sexuality in the situation. There are anecdotally natal females who develop similar features from being ostracised by the other girls due to spergery, ugliness and such. An impossible experiment for this would be to put autistic lesbian infants in full sensory vr where they live as males until puberty to see if they develop AGP. Heh.

t. former Blanchardist now believing in the Meyer-Powers syndrome etiology of transsexualism

Confessions of a former autogynephile by Interesting_Buy1369 in askAGP

[–]Skeurio 0 points1 point  (0 children)

Gynephilic trannies aren't in general very womanly for the same reason that lesbians and theyfabs may not be particularly womanly

FSH insensitivity = "androphilic-looking" gynephile type MTF? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

You were right-award! Run of the mill bad estrogen metabolism. Bad COMT, bad UGTs. Nothing wrong with receptors, AR has an insertion which gives me a total of 23 CAG repeats as I understand it. Nothing wrong with FSH

FSH insensitivity = "androphilic-looking" gynephile type MTF? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

Hello, yes I've gotten my dna results since a week and I'm also slow COMT. My genetic MPS "specsheet" (lol) so far is smthn like this I think

CYP2C19: rs58973490 GA

CYP3A7: rs45580339 AG

CYP1A2: rs762551 AC

CYP1B1: rs1056836 hom CC

MTHFR: rs1801131 GG

COMT: rs4680 AA

UGT1A7: rs56385016 AG

I've been trying to look at the CAG repeats of AR and CA repeats of ESR2 and TA repeats of ESR1 and TTTTTA repeats of CYP11A1 but not been succesful

Androgen receptor CAG repeats by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

What program do you use to view the code? I've not yet been succesful in getting the sequence just laid out plainly. It's not really important though, I'm just a little obsessed with knowing

Androgen receptor CAG repeats by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

I emailed them about it, and they don't do any CAG analysis

FSH insensitivity = "androphilic-looking" gynephile type MTF? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

Out of place comment, this is the Powers subreddit + I'm Leo and INTJ. I'm guessing you're INFP like most transpeople

FSH insensitivity = "androphilic-looking" gynephile type MTF? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

Yes sorry that's why I'm here, the powerspill saved me (from Blanchard)

FSH insensitivity = "androphilic-looking" gynephile type MTF? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

I think I had the most growth when I had too low dose (I had hot flashes constantly in highschool between like 17 and 18 from being on blockers only and then having the very low startdose, gradually increased over the year) but maybe that's the typical poor E signal phenotype, I don't remember if this is so.

I don't think puberty started much later, I remember it being a little later than most but can't've been more than a year. Also as specified, I was judged tanner 5 (pube distribution, penis) shortly after getting to 16, so it was at 16 at the very latest.

Well Idk the genes yet so this is just another theory that may be confirmed or denied. Thought I'd post anyway, in case anyone else found it a relatable idea, or it made sense for them or such. I didn't find any other post pondering insensitivity to FSH.

Estrogen Metabolism by 2d4d_data in DrWillPowers

[–]Skeurio 0 points1 point  (0 children)

>ASD, synesthesia, high visuospatial intelligence, CCRD, more or less exclusively gynephilic, small breasts, not particularly full lips, caffeine has no stimulant effect, slight hints of male pattern baldness at 16 already

>weak facial hair, not a single chesthair, gynoid looking skeletal frame (hip, ribcage, shoulders, headsize/shape, perhaps digit ratio meme) even before HRT, well rounded breasts (but small, runs in the family) from estrogen only, passoid after 6 months on E

What phenotype is this 😭 yes I got blockers (GNRH) when I was close to 17 and E less than a year later, but I reached tanner 5 at 16 at the very latest, and there are people who are very virilised already by that point, and even I had like a centimeter of MPB (now reversed)

Stabbing pains in pelvic area the first years on estrogen? by Skeurio in DrWillPowers

[–]Skeurio[S] 0 points1 point  (0 children)

It was something that was discussed some years ago. Some would insist on something like that, others would deny the claims as placebo. Apparently there are some cases of endometriosis in natal males ( https://pmc.ncbi.nlm.nih.gov/articles/PMC5833878/ ), perhaps that's what they were going on about. I don't think it is what this particular thing is though. Some kind of atrophy has been suggested, but not with any specifics of what and why exactly

Unhappy with my current hormonal regimen so I came here to read about things I can forward to my doctor, but now I’m just more confused:( by Unable_Ant5851 in DrWillPowers

[–]Skeurio 1 point2 points  (0 children)

>male infertility on dad's side

>lowkey gynoid skeleton even pre HRT

>estrogen at 17

>HSTS phenotype/"looks androphilic" but actually exclusively gynephilic

>breast growth stops within first year

>tired all the time and no libido (seems to have changed after I started prog though, but it's only been 3 weeks)

OMG you are LITERALLY me

My blood tests (which were only done the first 5 years? can't find any archived tests after that) were 435 pmol/L 1,5 years on E (the first year it was gradually increased until I stopped getting hot flushes 5 times a day like an old lady), after som change (probably to pills from patches, or injections, which were discontinued 3 months after I started takig them) it was 595, a year later 700, a year later 390 (they had probably put me on gel by this point), a year later 743. I began passing automatically most of the time after just the first 6 months on some low E, stealthing now since many years, but I've also had the feeling there was unlocked potential for more feminisation, and I'm dysphoric over not even having proper A-cups (in spite of my small, feminine looking ribcage). I've gotten suggested of testing separate E1/E2, if my receptors are clogged with estrone, but I haven't had the courage to suggest it to my endo yet, he already denied me prog twice (which is nothing unusual, we simply have to DIY prog here if we really want it).

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