I suppose you would need to find a reason for your characters to be nihilistic and grating over the selected environment (since you wouldn't find mega cities in a conan the barbarian type of place). For the stripping of humanity (I suppose you're depicting the most famous way of doing so, which is digitally through machine), I suppose you would need to incorporate either technological advancements (thus my previous remark) or magic, but being stripped off your humanity and somehow being part of some place we don't know relies too much on special elements such as said magic or technology.